Reversible global aphasia as a side effect of quetiapine: a case report and literature review

Figures & data

Table 1 Reported medication causing aphasia in literature review

Drug	Symptoms	Mechanism	Level of evidence
Ipilimumab^Citation10	Aphasia, tremor and ataxia, myocloni, hallucinations, anxiety and agitation in turns with somnolence	Unclear, suspect related to anti-thyroid antibodies	Case report
Immunomodulatory drugs^Citation11 (thalidomide, lenalidomide, pomalidomide)	Reversible coma, amnesia, expressive aphasia, and dysarthria	Central neurotoxicity	Case series
Lamotrigine^Citation12	Global aphasia	EEG showed continuous spikes and waves	Case report
Vigabatrin^Citation13	Aphasia disorder	Unclear	Case report
Sulfasalazine^Citation14	Dysphasia, seizures, rash	Unclear	Case report
Cyclosporine A^Citation15	Aphasia	Central neurotoxicity	Case report
Ifosfamide^Citation16	Confusion, aphasia, hallucinations, and coma	Central neurotoxicity	Case series
Phenylpropanolamine^Citation17	Acute memory loss and nominal aphasia	Unclear	Case report
Contrast (cardiac catheterization)^Citation18	Encephalopathy, motor and sensory disturbances, vision disturbance, ophthalmoplegia, aphasia, and seizures	1. Disruption of the BBB and direct neuronal injury; 2. Transient vasoconstriction	Case series
Metrizamide myelography^Citation19	Expressive dysphasia	Neurotoxic reaction	Case series
Naftidrofuryl oxalate^Citation20	Aphasia	Unclear	Case report
Cisplatin^Citation21	Aphasia, confusion, and agitation	Central neurotoxicity	Case report

Abbreviations: EEG, electroencephalography; BBB, blood–brain barrier.

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