Estimating cost savings of pharmacogenetic testing for depression in real-world clinical settings

Figures & data

Table 1 Depression clinical outcomes at week 12

	Remitters, %	Nonresponders, %
NeuroIDgenetix^® guided (experimental control)	35	27
Standard of care (control group)	13	64

Note: Data from Bradley et al.²¹

Figure 1 Major depressive disorder cost.

Note: Data retrieved from Greenberg et al⁹ to show which costs were included and converted to 2016 USD$.

Table 3 Patients requiring treatment

	NeuroI Dgenetix, %	Control, %	Difference, %
Patients requiring	65	87	22
treatment (non-remitters)

Note: Data from Bradley et al.²¹

Table 2 Annualized cost of MDD management in 2016 by treatment status

	Remitter	Nonresponder	Difference in cost
Estimated cost	USD$7,486	USD$34,585	USD$27,099

Abbreviation: MDD, major depressive disorder.

Figure 2 Cost-savings calculation.

Table 4 Published per-patient savings using genetic testing to guide medication management (adjusted to 2016 dollars)

	Present findings 2016	Winner et al^Citation27	Chou et al^Citation28
Per-patient savings	USD$5,962	USD$6,193	USD$7,112–USD$10,667

BradleyPShiekhMMehraVImproved efficacy with targeted pharmacogenetic-guided treatment of patients with depression and anxiety: a randomized clinical trial demonstrating clinical utilityJ Psychiatr Res20179610010728992526

 PubMed Web of Science ®Google Scholar

GreenbergPEFournierAASisitskyTPikeCTKesslerRCThe economic burden of adults with major depressive disorder in the United States (2005 and 2010)J Clin Psychiatry201576215516225742202

 PubMed Web of Science ®Google Scholar

WinnerJAllenJDAltarCASpahic-MihajlovicAPsychiatric pharmacogenomics predicts health resource utilization of outpatients with anxiety and depressionTransl Psychiatry20133e24223511609

 PubMed Web of Science ®Google Scholar

ChouWHYanFXdeLeonJExtension of a pilot study: impact from the cytochrome P4502D6 polymorphism on outcome and costs associated with severe mental illnessJ Clin Psychopharmacol200020224625110770465

 PubMed Web of Science ®Google Scholar