Investigation of ischemic and demyelinating lesions by cerebral vasoreactivity based on transcranial Doppler sonography: a comparative study

Figures & data

Table 1 Baseline characteristics of 112 patients and controls included in the current study

	MS (n = 28)	Control (n = 28)	Lacunar infarction (n = 28)	Control (n = 28)
Age (years)	29.85 ± 6.8	30.57 ± 6.6	52.1 ± 10.2	51.8 ± 9.7
Gender
Men (%)	7 (25.0%)	7 (25.0%)	17 (60.7%)	17 (35.4%)
Women (%)	21 (75.0%)	21 (75.0%)	11 (39.3%)	11 (39.3%)
Disease duration (months)	36.3 ± 12.6	N/A	N/A	N/A
EDSS	2.83 ± 1.56	N/A	N/A	N/A

Abbreviations: EDSS, Extended Disability Status Scale; ms, multiple sclerosis.

Table 2 TCD sonography characteristics of subjects with lacunar infarction and healthy individuals

	Lacunar infarction (n = 28)	Controls (n = 28)	p-value
BHI (%)	0.8 ± 0.4	1.2 ± 0.3	<0.001
MFVrest	47.2 ± 14.2	51.4 ± 13.4	0.264
MFVapnea	58.5 ± 17.7	63.9 ± 14.8	0.277
MFV variations	11.2 ± 6.4	12.4 ± 11.9	0.649

Abbreviations: BHI, breath-holding index; MFV, mean flow velocity; TCD, transcranial Doppler.

Table 3 TCD sonography characteristics of subjects with MS and healthy individuals

	MS (n = 28)	Controls (n = 28)	p-value
BHI (%)	1.02 ± 0.4	1.02 ± 0.3	0.993
MFVrest	57.6 ± 14.7	58.6 ± 19.2	0.849
MFVapnea	74.4 ± 18.6	69.9 ± 20.7	0.448
MFV variations	16.7 ± 8.1	11.3 ± 10.8	0.057

Abbreviations: BHI, breath-holding index; MFV, mean flow velocity; MS, multiple sclerosis; TCD, transcranial Doppler.

Table 4 TCD sonography characteristics of subjects with MS and lacunar infarctions

	Lacunar infarction (n = 28)	MS (n = 28)	p-value
BHI (%)	0.8 ± 0.4	1.02 ± 0.4	0.040
MFVrest	47.2 ± 14.2	54.8 ± 2.3	0.010
MFVapnea	58.5 ± 17.7	74.4 ± 18.6	0.002
MFV variations	11.2 ± 6.4	16.7 ± 8.1	0.007

Abbreviations: BHI, breath-holding index; MFV, mean flow velocity; MS, multiple sclerosis; TCD, transcranial Doppler.