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Original Research

Significant association of BDNF rs6265 G>A polymorphism with susceptibility to epilepsy: a meta-analysis

, , , , , , & show all
Pages 1035-1046 | Published online: 16 Apr 2018

Figures & data

Table 1 Characteristics of case–control studies on BDNF rs6265 G>A polymorphism and epilepsy risk included in the meta-analysis

Figure 1 Flow diagram of the study selection process.

Figure 1 Flow diagram of the study selection process.

Figure 2 OR and 95% CIs of the associations between BDNF rs6265 G>A polymorphism and epilepsy susceptibility in GA+AA vs GG model.

Figure 2 OR and 95% CIs of the associations between BDNF rs6265 G>A polymorphism and epilepsy susceptibility in GA+AA vs GG model.

Table 2 Summary ORs and 95% CIs of BDNF rs6265 G>A polymorphism and epilepsy risk

Figure 3 Sensitivity analysis by removing one study at a time to reflect the influence of the individual dataset on the pooled ORs in GA+AA vs GG model of BDNF rs6265 G>A polymorphism.

Figure 3 Sensitivity analysis by removing one study at a time to reflect the influence of the individual dataset on the pooled ORs in GA+AA vs GG model of BDNF rs6265 G>A polymorphism.

Figure 4 Cumulative meta-analyses according to publication year in GA+AA vs GG model of BDNF rs6265 G>A polymorphism.

Figure 4 Cumulative meta-analyses according to publication year in GA+AA vs GG model of BDNF rs6265 G>A polymorphism.

Figure 5 Funnel plot analysis to detect publication bias for GA+AA vs GG model of BDNF rs6265 G>A polymorphism.

Note: Circles represent the number of the studies.
Figure 5 Funnel plot analysis to detect publication bias for GA+AA vs GG model of BDNF rs6265 G>A polymorphism.

Figure S1 OR and 95% CIs of the associations between BDNF rs6265 G>A polymorphism and epilepsy susceptibility (A for A vs G model; B for GA vs GG model; C for AA vs GG model; and D for AA vs GG+GA model).

Figure S1 OR and 95% CIs of the associations between BDNF rs6265 G>A polymorphism and epilepsy susceptibility (A for A vs G model; B for GA vs GG model; C for AA vs GG model; and D for AA vs GG+GA model).

Figure S2 Sensitivity analysis through deleting each study to reflect the influence of the individual dataset to the pooled ORs in BDNF rs6265 G>A polymorphism and epilepsy susceptibility (A for A vs G model; B for GA vs GG model; C for AA vs GG model; and D for AA vs GG+GA model).

Figure S2 Sensitivity analysis through deleting each study to reflect the influence of the individual dataset to the pooled ORs in BDNF rs6265 G>A polymorphism and epilepsy susceptibility (A for A vs G model; B for GA vs GG model; C for AA vs GG model; and D for AA vs GG+GA model).
Figure S2 Sensitivity analysis through deleting each study to reflect the influence of the individual dataset to the pooled ORs in BDNF rs6265 G>A polymorphism and epilepsy susceptibility (A for A vs G model; B for GA vs GG model; C for AA vs GG model; and D for AA vs GG+GA model).

Figure S3 Cumulative meta-analyses according to publication year in BDNF rs6265 G>A polymorphism and epilepsy susceptibility (A for A vs G model; B for GA vs GG model; C for AA vs GG model; and D for AA vs GG+GA model).

Figure S3 Cumulative meta-analyses according to publication year in BDNF rs6265 G>A polymorphism and epilepsy susceptibility (A for A vs G model; B for GA vs GG model; C for AA vs GG model; and D for AA vs GG+GA model).

Figure S4 Funnel plot analysis to detect publication bias in BDNF rs6265 G>A polymorphism and epilepsy susceptibility (A for A vs G model; B for GA vs GG model; C for AA vs GG model; and D for AA vs GG+GA model).

Figure S4 Funnel plot analysis to detect publication bias in BDNF rs6265 G>A polymorphism and epilepsy susceptibility (A for A vs G model; B for GA vs GG model; C for AA vs GG model; and D for AA vs GG+GA model).