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Original Research

High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors

, &
Pages 587-596 | Published online: 19 Feb 2018

Figures & data

Table 1 Baseline characteristics of the studied sample

Table 2 Adjusted OR of depression for 8-OHdG levels in stroke patients

Figure 1 Serum levels of 8-OHdG and CAT in patients with PSD and those without depression.

Notes: (A) 8-OHdG levels, (B) CAT levels. In the box-and-whisker plots, the horizontal line in the middle of each box indicates the median value; the lower and upper ends of the box represent the 25th and 75th percentiles, respectively, and the peripheral lines extending to the outer fences represent 10th and 90th percentiles. *P<0.05; ***P<0.001 compared with the non-PSD group via Mann–Whitney U test.
Abbreviations: 8-OHdG, 8-hydroxy-2′-deoxyguanosine; CAT, catalase; PSD, post-stroke depression.
Figure 1 Serum levels of 8-OHdG and CAT in patients with PSD and those without depression.

Figure 2 Correlation between CAT and 8-OHdG levels in acute stroke patients or PSD patients.

Note: (A) In stroke patients, (B) in PSD patients.
Abbreviations: 8-OHdG, 8-hydroxy-2′-deoxyguanosine; CAT, catalase; PSD, post-stroke depression.
Figure 2 Correlation between CAT and 8-OHdG levels in acute stroke patients or PSD patients.

Figure 3 Receiver operator characteristic curve demonstrating sensitivity as a function of 1-specificity for predicting post-stroke depression within 1 month based on the serum 8-OHdG levels in stroke patients.

Abbreviation: 8-OHdG, 8-hydroxy-2′-deoxyguanosine.
Figure 3 Receiver operator characteristic curve demonstrating sensitivity as a function of 1-specificity for predicting post-stroke depression within 1 month based on the serum 8-OHdG levels in stroke patients.

Figure S1 Study flow chart.

Abbreviation: PSD, post-stroke depression.

Figure S1 Study flow chart.Abbreviation: PSD, post-stroke depression.

Table S1 Prescribed drugs employed of the studied subjects at admission

Table S2 Serum 8-OHdG and CAT levels according to the severity of stroke and depression

Table S3 Comparisons of serum 8-OHdG and CAT levels in patients with minor stroke and those with moderate-to-severe stroke

Table S4 Correlations between oxidative stress markers and NIHSS scores