Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors

Figures & data

Figure 1 Effects of three APDs on 5-HT_1A expression levels in the PFC (A′, A″), CPu (B′, B″), NAc (C′, C″), and Hipp (D′, D″) of female and male rats.

Notes: Sprague Dawley rats were treated chronically with aripiprazole (1.0 mg/kg, tid), olanzapine (1.0 mg/kg, tid), risperidone (0.3 mg/kg, tid), or control (vehicle). The number of samples per gender per group is 6. Data were expressed as mean ± SEM. *P<0.05 vs control. The representative bands of Western Blot are shown.
Abbreviations: APDs, antipsychotic drugs; CPu, caudate putamen; Hipp, hippocampus; 5-HT, serotonin; NAc, nucleus accumbens; PFC, prefrontal cortex; SEM, standard error of the mean; tid, three times daily.

Figure 2 Effects of three APDs on 5-HT_2A expression levels in the PFC (A′, A″), CPu (B′, B″), NAc (C′, C″), and Hipp (D′, D″) of female and male rats.

Notes: Sprague-Dawley rats were treated chronically with aripiprazole (1.0 mg/kg, tid), olanzapine (1.0 mg/kg, tid), risperidone (0.3 mg/kg, tid), or control (vehicle). The number of samples per gender per group is 6. Data expressed as mean ± SEM. **P<0.01 vs control. The representative bands of Western Blot are shown.
Abbreviations: APDs, antipsychotic drugs; CPu, caudate putamen; Hipp, hippocampus; NAc, nucleus accumbens; 5-HT, serotonin; PFC, prefrontal cortex; SEM, standard error of the mean; tid, three times daily.

Figure 3 Examples of 5-HT_2A receptor binding in the adult rat brain following childhood/adolescent APD treatment.

Notes: The schematic diagram is adapted from Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 6th edition. London: Elsevier; 2007. © Academic Press 2007.⁶⁸ Showing the level of Bregma for each investigated region (A: PFC, 4.68 mm; B: CPu and NAc, 1.08 mm; C: Hipp, −2.76 mm). (A′–C′) Examples of autoradiograms to demonstrate [³H]Ketanserin binding to 5-HT_2A receptors. The scale bar applies to all autoradiograms and is 2.0 mm for A′, 2.8 mm for B′, and 3.2 mm for C′.
Abbreviations: APD, antipsychotic drug; CPu, caudate putamen; Hipp, hippocampus; 5-HT, serotonin; NAc, nucleus accumbens; PFC, prefrontal cortex.

Figure 4 Effects of three APDs on 5-HT_2C expression levels in the PFC (A′, A″), CPu (B′, B″), NAc (C′, C″), and Hipp (D′, D″) of female and male rats.

Notes: Sprague Dawley rats were treated chronically with aripiprazole (1.0 mg/kg, tid), olanzapine (1.0 mg/kg, tid), risperidone (0.3 mg/kg, tid), or control (vehicle). The number of samples per gender per group is 6. Data expressed as mean ± SEM. *P<0.05, **P<0.01, ***P<0.001 vs control. The representative bands of Western Blot are shown.
Abbreviations: APDs, antipsychotic drugs; CPu, caudate putamen; Hipp, hippocampus; 5-HT, serotonin; NAc, nucleus accumbens; PFC, prefrontal cortex; SEM, standard error of the mean; tid, three times daily.

PaxinosGWatsonCThe Rat Brain in Stereotaxic Coordinates6th editionLondonElsevier2007

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