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Case Report

Allergy to chlorpromazine and valproic acid following carbamazepine hypersensitivity in a patient with an HLA-B*4601 allele

, , , , &
Pages 1139-1142 | Published online: 04 May 2018

Figures & data

Figure 1 Schematic drawing of the course of treatment. The day the patient received a brain injury due to a fall down a flight of stairs is set at Day 0. Administered doses of CBZ, CPZ, VPA, quetiapine, and mianserin are presented in mg/day. Aside from these drugs, haloperidol (<3 mg/day) or risperidone (<3 mg/day) were used to treat psychomotor excitement with delusional thoughts during the entire course of treatment. Serum concentrations of CBZ and VPA at the indicated time points (arrows) are given in µg/mL. The ratio of eosinophils in the white blood cells is presented as a percentage, and the levels of γ-GTP and ALP are presented in U/L. The normal ranges for each parameter and the therapeutic effective serum concentrations of the drugs are indicated in parentheses.

Abbreviations: CBZ, carbamazepine; CPZ, chlorpromazine; VPA, valproic acid; γ-GTP, gamma-glutamyl transpeptidase; ALP, alkaline phosphatase.
Figure 1 Schematic drawing of the course of treatment. The day the patient received a brain injury due to a fall down a flight of stairs is set at Day 0. Administered doses of CBZ, CPZ, VPA, quetiapine, and mianserin are presented in mg/day. Aside from these drugs, haloperidol (<3 mg/day) or risperidone (<3 mg/day) were used to treat psychomotor excitement with delusional thoughts during the entire course of treatment. Serum concentrations of CBZ and VPA at the indicated time points (arrows) are given in µg/mL. The ratio of eosinophils in the white blood cells is presented as a percentage, and the levels of γ-GTP and ALP are presented in U/L. The normal ranges for each parameter and the therapeutic effective serum concentrations of the drugs are indicated in parentheses.