Effect of serum inflammatory markers on the prognosis of adult and pediatric patients with Guillain–Barré syndrome

Figures & data

Table 1 Comparisons of inflammatory markers between AIDP and axonal subgroups

	Adult		Pediatric		p	p1
	AIDP (n=22)	Axonal (n=14)	AIDP (n=18)	Axonal (n=14)
Age, years	50.90±20.94	44.71±15.27	6.55±4.35	4.56±5.04	0.346	0.059
NLR	3.44±1.94	3.98±1.34	1.43±0.83	2.18±1.31	0.368	0.070
PLR	162.58±62.18	171.75±69.11	104.19±35.85	118.37±72.67	0.682	0.985
CRP, mg/dL	0.79±1.88	0.82±0.47	0.05±0.07	0.20±0.31	0.950	0.122
Albumin, gr/dL	3.68±0.59	3.31±0.64	4.29±0.39	3.98±0.47	0.121	0.060

Notes: The data were presented as mean ± SD. p: significance between AIDP and axonal group in GBS-A patients, p1: significance between AIDP and axonal group in GBS-P patients.

Abbreviations: AIDP, acute inflammatory demyelinating polyradiculoneuropathy; CRP, C-reactive protein; NLR, neutrophil–lymphocyte ratio; PLR, platelet–lymphocyte ratio.

Table 2 The demographic and laboratory characteristics of GBS-A and GBS-P patients

	Admission		Discharged		Control		p	p1	p2
	HDS-A<3	HDS-A≥3	HDS-D<3	HDS-D≥3	HDS-C<3	HDS-C≥3
GBS-A	n=9	n=27	n=18	n=18	n=13	n=15
Age, years	43.66±19.66	50.11±18.80	44.66±18.67	52.33±18.96	45.46±19.70	47.33±13.98	0.405	0.230	0.783
NLR	2.29±0.88	4.10±1.72	2.92±1.69	4.38±1.49	2.80±1.29	4.25±1.39	0.000	0.009	0.010
PLR	163.83±63.17	166.92±65.63	172.58±67.40	159.71±61.97	180.44±71.06	156.40±52.21	0.902	0.555	0.513
CRP, mg/dL	0.12±0.12	1.03±1.66	0.34±0.36	1.27±1.99	0.34±0.35	0.76±0.46	0.000	0.001	0.036
Albumin, gr/dL	3.97±0.20	3.45±0.65	3.99±0.45	3.15±0.49	3.92±0.53	3.17±0.52	0.007	0.000	0.003
GBS-P	n=6	n=26	n=11	n=21	n=19	n=7	p3	p4	p5
Age, years	6.93±4.0	5.39±4.86	6.86±4.23	5.06±4.90	6.75±4.72	3.11±4.12	0.308	0.096	0.030
NLR	1.51±0.86	1.82±1.17	1.47±0.86	1.91±1.22	1.39±0.86	2.80±1.35	0.482	0.250	0.004
PLR	114.83±43.95	110.70±57.53	102.21±34.86	116.33±62.80	95.09±34.70	145.63±81.35	0.359	0.766	0.066
CRP, mg/dL	0.07±0.11	0.13±0.24	0.05±0.08	0.15±0.26	0.13±0.26	0.10±0.15	0.492	0.170	0.638
Albumin, gr/dL	4.38±0.39	4.10±0.45	4.35±0.30	4.06±0.49	4.27±0.41	3.91±0.52	0.179	0.088	0.079

Notes: p, significance between adult HDS-A<3 and adult HDS-A≥3; p1, significance between adult HDS-D<3 and adult HDS-D≥3; p2, significance between adult HDS-C<3 and adult HDS-C≥3; p3, significance between pediatric HDS-A<3 and pediatric HDS-A≥3; p4, pediatric HDS-D<3 and pediatric HDS-D≥3; p5, pediatric HDS-C<3 and pediatric HDS-C≥3.

Abbreviations: CRP, C-reactive protein; GBS, Guillain–Barré syndrome; GBS-A, adult GBS; GBS-P, pediatric GBS; HDS-A, Hughes disability scale-admission; HDS-C, Hughes disability scale – control; HDS-D, Hughes disability scale – discharged; NLR, neutrophil–lymphocyte ratio; PLR, platelet–lymphocyte ratio.

Table 3 Comparisons of inflammatory markers between adults and children

	GBS-A	GBS-P	p-value
NLR	3.65±1.73	1.76±1.21	0.000
PLR	166.15±64.14	111.48±54.62	0.000
CRP, mg/dL	0.80±1.48	0.16±0.30	0.000
Albumin, gr/dL	3.52±0.63	4.15±0.44	0.000

Abbreviations: CRP, C-reactive protein; GBS, Guillain–Barré syndrome; GBS-A, adult GBS; GBS-P, pediatric GBS; NLR, neutrophil–lymphocyte ratio; PLR, platelet–lymphocyte ratio.

Table 4 Comparisons of inflammatory markers between GBS-A and GBS-P patients with control groups

	GBS-A	GBS-AC	GBS-P	GBS-PC	p	p1
Age, years	48.50±18.95	42.45±19.86	5.68±4.69	6.73±3.95	0.200	0.312
NLR	3.65±1.73	1.91±0.59	1.79±1.12	1.18±0.61	0.000	0.041
PLR	166.15±64.14	120.61±23.81	110.39±54.50	101.41±12.92	0.000	0.933
CRP, mg/dL	0.80±1.48	0.12±0.12	0.21±0.34	0.05±0.08	0.000	0.020
Albumin, gr/dL	3.52±0.63	3.84±0.42	4.15±0.44	4.05±0.23	0.026	0.242

Notes: p, significance between GBS-A and GBS-AC; p1, significance between GBS-P and GBS-PC.

Abbreviations: CRP, C-reactive protein; GBS, Guillain–Barré syndrome; GBS-A, adult GBS; AC, adult control; GBS-P, pediatric GBS; PC, pediatric control; NLR, neutrophil–lymphocyte ratio; PLR, platelet–lymphocyte ratio.