Dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series

Figures & data

Table 1 Case histories

Case	Duration of major depressive episode	Personal and family history of bipolar	Comorbidity with medical illnesses
A. Female, age 50	4 months	No	No
B. Female, age 66	2 months	No	Hypertension, rheumatoid arthritis
C. Female, age 45	6 months	No	SLE

Abbreviation: SLE, systemic lupus erythematosus.

Table 2 Course of escitalopram treatment-emergent mania

Case	Duration of escitalopram 10 mg/day treatment	Duration of escitalopram 20 mg/day treatment before mania	Days before resolution of mania/hypomania after discontinuation of escitalopram	Medications after mania/hypomania	Follow-up results
A.	14 days	14 days	Within 2 months	Lithium 800 mg/day	2 years, no hypomanic switch
B.	14 days	21 days	Within 1 month	Olanzapine 5 mg/day	9 months, no manic switch
C.	7 days	14 days	Within 14 days	Sodium valproate 400 mg/day	6 months, no hypomanic switch