Positive metacognitions about alcohol mediate the relationship between FKBP5 variability and problematic drinking in a sample of young women

Figures & data

Table 1 Descriptive statistics of AUDIT and PAMS in subgroups differing in levels of CA

	Low level of CA N=234	High level of CA N=268	t-test results
AUDIT	M=6.11 SD=4.06	M=7.85 SD=4.94	t(498.21) =−4.32 P<0.001
PAMS	M=24.46 SD=6.44	M=26.82 SD=6.59	t(498) =−4.02 P<0.001
PAMS1	M=18.93 SD=5.36	M=20.61 SD=5.46	t(498) =−3.47 P<0.01
PAMS2	M=5.55 SD=1.72	M=6.19 SD=1.92	t(500) =−3.96 P<0.001

Abbreviations: AUDIT, Alcohol Use Disorders Identification Test; CA, childhood abuse; PAMS, Positive Alcohol Metacognitions Scale.

Table 2 Descriptive statistics of PAMS total score and PAMS1 in subgroups differing in genotype for rs755658 and rs1334894

SNP	Genotype	PAMS total score			PAMS1
		n	M	SE	n	M	SE
rs755658	g/g	405	25.31	0.32	405	19.49	0.266
	a/g	74	27.47	0.86	74	21.26	0.694
	a/a	9	29.44	1.676	9	23.11	1.504
	a/g-a/a	83	27.69	0.788	83	21.46	0.64
rs1334894	c/c	404	25.30	0.321	404	19.49	0.267
	c/t	75	27.49	0.846	75	21.27	0.68
	t/t	9	29.44	1.676	9	23.11	1.504
	c/t-t/t	84	27.70	0.774	84	21.46	0.629

Figure 1 Means and standard errors of PAMS total and PAMS1 scores in groups differing in rs755658 and rs1334894.

Notes: (A) Descriptive statistics for the association of rs755658 and PAMS total score; (B) descriptive statistics for the association of rs755658 and PAMS1 score; (C) descriptive statistics for the association of rs1334894 and PAMS total score; (D) descriptive statistics for the association of rs1334894 and PAMS1 score.

Table 3 Analyses of mediation of the relationship between genotype and AUDIT total score

(a) rs755658
Mediator	PAMS total score					PAMS1
	Effect	SE	95% CI	t	P-value	Effect	SE	95% CI	t	P-value
Total effect	1.08	0.554	(−0.004; 2.17)	1.96	0.051	1.08	0.554	(−0.004; 2.17)	1.96	0.051
Direct effect	0.293	0.499	(−0.69; 1.27)	0.59	0.556	0.33	0.505	(−0.66; 1.03)	0.66	0.509
	Effect	SE	Bootstrapped 95% CI	Significance		Effect	SE	Bootstrapped 95% CI	Significance
Indirect effect	0.79	0.289	(0.272; 1.394)	Significant		0.75	0.27	(0.24; 1.32)	Significant

(b) rs1334894
Mediator	PAMS total score					PAMS1
	Effect	SE	95% CI	t	P-value	Effect	SE	95% CI	t	P-value
Total effect	1.17	0.55	(0.088; 2.25)	2.12	0.034	1.17	0.55	(0.088; 2.25)	2.12	0.034
Direct effect	0.376	0.496	(−0.6; 1.35)	0.75	0.449	0.42	0.503	(−0.57; 1.41)	0.83	0.405
	Effect	SE	Bootstrapped 95% CI	Significance		Effect	SE	Bootstrapped 95% CI	Significance
Indirect effect	0.79	0.28	(0.3; 1.38)	Significant		0.75	0.26	(0.26; 1.29)	Significant

Abbreviations: AUDIT, Alcohol Use Disorders Identification Test; PAMS, Positive Alcohol Metacognitions Scale.