Chinese version of Montreal Cognitive Assessment Basic for discrimination among different severities of Alzheimer’s disease

Figures & data

Table 1 Best MoCA-BC subtests and the corresponding cutoff scores recommended for discrimination between normal controls, mild cognitive impairment, mild and moderate Alzheimer’s disease

Diagnosis groups	Recommended tests	Best cutoff scores
		Low-level education	Mid-level education	High-level education
NC vs MCI	MoCA-BC-T	19	22	24
	MoCA-BC-MIS	8
MCI vs AD	MoCA-BC-T	13	15	16
	MoCA-BC-NM	9	10
Mild vs moderate AD	MoCA-BC-T	10	11	13
	MoCA-BC-NM	7	8

Abbreviations: MoCA-BC, Chinese version of Montreal Cognitive Assessment Basic; NC, cognitively normal controls; MCI, mild cognitive impairment; AD, Alzheimer’s disease; MoCA-BC-T, total score of MoCA-BC; MoCA-BC-MIS, the Memory Index Score of MoCA-BC; MoCA-BC-NM, the Non-memory Index Score of MoCA-BC.

Table S1 Demographic information and mean scores of MoCA-BC and MMSE

Index	NC (n=520)	MCI (n=663)	Mild AD (n=345)	Moderate AD (n=441)	F (P)	P-value*
Age	68.77 (8.24)	68.21 (8.49)	69.27 (8.76)	69.18 (9.05)	0.172
Education	10.68 (4.11)	10.80 (3.95)	10.21 (4.07)	9.16 (4.33)	<0.001	<0.05
Sex (M/F)	178/342	305/358	162/183	194/247		sig <0.001
MMSE	27.88 (1.79)	26.38 (1.87)	21.92 (1.88)	16.30 (2.81)	<0.001	<0.05
MoCA-BC-T	24.10 (3.40)	19.37 (3.74)	14.38 (3.62)	9.51 (3.72)	<0.001	<0.05
MoCA-BC-MIS	10.24 (6.63)	4.75 (3.91)	1.99 (2.86)	0.96 (2.04)	<0.001	<0.05
MoCA-BC-NM	13.57 (1.39)	12.17 (1.80)	9.78 (2.10)	7.01 (2.28)	<0.001	<0.05

Note:

* NC vs MCI, NC vs mild AD, NC vs moderate AD, MCI vs mild AD, MCI vs moderate AD, mild AD vs moderate AD.

Abbreviations: MoCA-BC, Chinese version of Montreal Cognitive Assessment Basic; MMSE, mini-mental state examination; NC, cognitively normal controls; MCI, mild cognitive impairment; AD, Alzheimer’s disease; MoCA-BC-T, total score of MoCA-BC; MoCA-BC-MIS, the Memory Index Score of MoCA-BC; MoCA-BC-NM, the Non-memory Index Score of MoCA-BC; sig, significant.

Table S2 Demographic characteristics and mean scores according to level of education

Low-level education group
Index (mean ± SD)	NC (n=82)	MCI (n=96)	Mild AD (n=80)	Moderate AD (n=132)	F (P)	P-value
Age	68.2±8.8	67.5±8.2	68.2±7.6	68.4±8.5	0.869	–
Education, years	3.9±2.3	4.0±2.1	4.5±2.1	3.7±2.2	0.135	–
Sex (M/F)	27/55	37/59	28/52	43/89	–	sig 0.800
MMSE total score	27.1±2.6	25.3±2.5	20.9±2.8	15.8±2.8	<0.001	<0.001
MoCA-BC-T score	20.6±4.7	16.4±3.8	12.9±3.0	8.7±3.7	<0.001	<0.001
MoCA-BC-MIS score	9.7±4.5	4.5±3.9	2.5±3.4	1.2±2.4	<0.001	<0.001
MoCA-BC-NM score	12.4±2.1	11.0±2.1	9.2±2.1	6.7±2.4	<0.001	<0.001
Mid-level education group
Index (mean ± SD)	NC (n=285)	MCI (n=379)	Mild AD (n=180)	Moderate AD (n=225)	F (P)	P-value
Age	67.8±8.3	66.9±8.3	68.6±9.2	68.5±9.5	0.080	–
Education, years	10.1±1.9	10.2±1.7	10.4±1.5	10.1±1.5	0.314	–
Sex (M/F)	87/198	165/214	79/101	106/119	–	sig <0.001
MMSE total	28.0±1.5	26.5±1.7	22.0±1.3	16.4±2.8	<0.001	<0.001
MoCA-BC-T	24.4±2.6	19.6±3.5	14.7±3.5	9.6±3.5	<0.001	<0.001
MoCA-BC-MIS	10.4±3.3	5.1±3.9	1.8±2.8	0.9±1.9	<0.001	<0.001
MoCA-BC-NM	13.7±1.2	12.3±1.7	9.9±2.0	7.0±2.2	<0.001	<0.001
High-level education group
Index (mean ± SD)	NC (n=153)	MCI (n=188)	Mild AD (n=85)	Moderate AD (n=84)	F (P)	P-value
Age	71.0±7.5	71.2±8.3	71.7±8.4	72.3±7.9	0.607	–
Education, years	15.3±1.2	15.4±1.2	15.2±1.5	15.1±1.1	0.108	–
Sex (M/F)	64/89	103/85	55/30	45/39	–	sig 0.006
MMSE total	28.1±1.6	26.6±1.7	22.7±1.5	16.9±2.7	<0.001	<0.001
MoCA-BC-T	25.3±2.6	20.4±3.3	15.2±4.0	10.6±3.9	<0.001	<0.001
MoCA-BC-MIS	10.2±3.7	4.3±3.9	1.9±2.4	0.8±1.8	<0.001	<0.001
MoCA-BC-NM	13.9±1.0	12.5±1.6	10.0±2.3	7.4±2.3	<0.001	<0.001

Note: NC vs MCI, NC vs mild AD, NC vs moderate AD, MCI vs mild AD, MCI vs moderate AD, mild AD vs moderate AD.

Abbreviations: MMSE, mini-mental state examination; MoCA-BC, Chinese version of Montreal Cognitive Assessment Basic; NC, cognitively normal controls; MCI, mild cognitive impairment; AD, Alzheimer’s disease; MoCA-BC-T, total score of MoCA-BC; MoCA-BC-MIS, the Memory Index Score of MoCA-BC; MoCA-BC-NM, the Non-memory Index Score of MoCA-BC.

Table S3 MoCA-BC and its subtests to discriminate among NC, MCI, mild and moderate AD

Diagnosis groups	Tests	Cutoff score	Sensitivity %	Specificity %	AUC
Low-level education group (≤6 years)
NC vs MCI	MoCA-BC-T	19	0.794	0.706	0.810
	MoCA-BC-MIS	8	0.738	0.745	0.816
	MoCA-BC-NM	12	0.738	0.578	0.708
MCI vs AD	MoCA-BC-T	13	0.774	0.794	0.865
	MoCA-BC-MIS	2	0.731	0.673	0.735
	MoCA-BC-NM	9	0.774	0.757	0.836
Mild vs moderate AD	MoCA-BC-T	10	0.705	0.812	0.807
	MoCA-BC-MIS	0	0.727	0.487	0.616
	MoCA-BC-NM	7	0.659	0.850	0.793
Mid-level education group (7–12 years)
NC vs MCI	MoCA-BC-T	22	0.777	0.830	0.873
	MoCA-BC-MIS	8	0.793	0.740	0.846
	MoCA-BC-NM	13	0.731	0.691	0.769
MCI vs AD	MoCA-BC-T	15	0.790	0.889	0.914
	MoCA-BC-MIS	2	0.783	0.698	0.776
	MoCA-BC-NM	10	0.802	0.853	0.902
Mild vs moderate AD	MoCA-BC-T	11	0.729	0.828	0.847
	MoCA-BC-MIS	0	0.756	0.417	0.595
	MoCA-BC-NM	8	0.729	0.772	0.833
High-level education group (>12 years)
NC vs MCI	MoCA-BC-T	24	0.899	0.686	0.885
	MoCA-BC-MIS	8	0.803	0.725	0.855
	MoCA-BC-NM	13	0.681	0.752	0.769
MCI vs AD	MoCA-BC-T	16	0.787	0.867	0.906
	MoCA-BC-MIS	2	0.746	0.622	0.719
	MoCA-BC-NM	10	0.734	0.894	0.892
Mild vs moderate AD	MoCA-BC-T	13	0.762	0.694	0.792
	MoCA-BC-MIS	1	0.798	0.447	0.623
	MoCA-BC-NM	8	0.714	0.729	0.792

Abbreviations: MoCA-BC, Chinese version of Montreal Cognitive Assessment Basic; NC, cognitively normal controls; MCI, mild cognitive impairment; AD, Alzheimer’s disease; MoCA-BC-T, total score of MoCA-BC; MoCA-BC-MIS, the Memory Index Score of MoCA-BC; MoCA-BC-NM, the Non-memory Index Score of MoCA-BC; AUC, area under the curve.