Figures & data
Notes: The classification schematic flow using the combined sMRI and rs-fMRI features. In detail, 1,024 features from GMV, 1,024 features from ReHo, 1,024 features from ALFF, and 1,024 features from DC concatenated into a 4,096-dimensional vector. SVM-RFE and 10-fold cross validation were applied for feature selection and classifier training.
Abbreviations: AAL, automated anatomical labeling; ALFF, amplitude of low-frequency fluctuation; DC, degree centrality; GMV, gray matter volume; rs-fMRI, resting-state functional magnetic resonance imaging; RFE, recursive feature elimination; ReHo, regional homogeneity; sMRI, structural magnetic resonance imaging; SVM, support vector machine.
Abbreviations: AAL, automated anatomical labeling; ALFF, amplitude of low-frequency fluctuation; DC, degree centrality; GMV, gray matter volume; rs-fMRI, resting-state functional magnetic resonance imaging; RFE, recursive feature elimination; ReHo, regional homogeneity; sMRI, structural magnetic resonance imaging; SVM, support vector machine.
Notes: (I) The warm color means that FESZ patients’ structural brain changes and functional activities were significantly higher than NCs, and the cool color means the opposite. (II) The warm color means that the CSZ patients’ structural brain changes and functional activities were significantly higher than NCs, and the cool color means the opposite. (III) The warm color means that the FESZ patients’ structural brain changes and functional activities were significantly higher than CSZ patients’ structural brain changes and functional activities, and the cool color means the opposite. The 3D maps were made using BrainNet Viewer (http://www.nitrc.org/projects/bnv/), and the 3D perspective drawing was made using ParaView (https://www.paraview.org/).
Abbreviations: ALFF, amplitude of low-frequency fluctuation; CSZ, chronic schizophrenia; DC, degree centrality; FESZ, first-episode drug-naive schizophrenia; GMV, gray matter volume; NC, normal control; ReHo, regional homogeneity.
Abbreviations: ALFF, amplitude of low-frequency fluctuation; CSZ, chronic schizophrenia; DC, degree centrality; FESZ, first-episode drug-naive schizophrenia; GMV, gray matter volume; NC, normal control; ReHo, regional homogeneity.
Notes: The classification between the FESZ and NC groups (blue line), the classification between the CSZ and NC groups (red line), and the classification between the FESZ and CSZ groups (black line). The areas under the ROC curve of the three classifiers were 0.88, 0.92, and 0.87, respectively.
Abbreviations: CSZ, chronic schizophrenia; FESZ, first-episode drug-naive schizophrenia; NC, normal control; ROC, receiver operating characteristic.
Abbreviations: CSZ, chronic schizophrenia; FESZ, first-episode drug-naive schizophrenia; NC, normal control; ROC, receiver operating characteristic.