The efficacy of a “cocktail therapy” on Parkinson’s disease with dementia

Figures & data

Table 1 Comparison of baseline data between two groups

	Test group	Control group	Statistic	p-value
Number of patients	30	30
Mean age (year)	68.8±8.7	67.9±9.5	t=0.383	>0.05
Gender, n
Male	16	16	χ^2=0.067	>0.05
Female	14	14
Course of disease (year)	1.9±0.9	1.8±0.8	t=0.455	>0.05
Education background, n
University	3	2	χ^2=0.222	>0.05
Middle school	22	23
Primary school	5	5
Occupation, n
Teacher	1	1	χ^2=0.026	>0.05
Doctor	1	0
Civil servant	3	2
Driver	2	2
Journalist	0	1
Sales clerk	1	1
Company manager	1	2
Athlete	1	1
Workers	17	16
Cook	1	2
Farmer	2	2
Patients with drinking history, n	21	20	χ^2=0.077	>0.05
Patients with smoking history, n	18	19	χ^2=0.071	>0.05

Notes: p>0.05, comparison of baseline data between two groups. The control group received 10 mg of donepezil hydrochloride tablets orally, once a day. The test group was treated with a “cocktail therapy”, which consisted of 10 mg of donepezil hydrochloride tablets taken orally, once a day; 200 mg of dl-3n-butylphthalide soft capsules taken orally, 15 mins before each meal, three times daily; 800 mg of oxiracetam capsules taken orally, three times daily; and 80 mg of Ginkgo biloba extract tablets taken orally, three times daily.

Table 2 Comparison of MoCA scores in the test and control groups before and after treatment (mean ± SD)

Groups	Cases	Before the treatment	3 months after the treatment	6 months after the treatment
Test group	30	16.19±2.14	17.28±2.49	18.53±2.06
Control group	30	16.37±2.61 F =4.196, P=0.035* F =5.203, P=0.014** F =4.724, P=0.027^#	16.81±2.17	17.08±2.35

Notes: *Indicates post-treatment comparison between two groups; **Indicates different time points before and after treatment for comparisons within the test group; ^#Indicates different time points before and after treatment for comparisons between the two groups. The control group received 10 mg of donepezil hydrochloride tablets orally, once a day. The test group was treated with a “cocktail therapy”, which consisted of 10 mg of donepezil hydrochloride tablets taken orally, once a day; 200 mg of dl-3n-butylphthalide soft capsules taken orally, 15 mins before each meal, three times daily; 800 mg of oxiracetam capsules taken orally, three times daily; and 80 mg of Ginkgo biloba extract tablets taken orally, three times daily.

Table 3 Comparison of different components of MoCA in the test and control groups before and after treatment (mean ± SD)

	Before the treatment		3 months after the treatment		6 months after the treatment
	Test group	Control group	Test group	Control group	Test group	Control group
Visual space and executive function	1.03±0.42	1.04±0.40	1.21±0.51	1.09±0.56	1.34±0.4	1.15±0.53^○
Naming	1.81±0.37	1.80±0.38	2.07±0.65	1.91±0.59	2.23±0.61	1.99±0.52^●
Attention	2.34±1.56	2.35±1.53	2.59±1.28	2.42±1.34	2.88±1.35	2.49±1.27^△
Language	0.52±0.28	0.53±0.25	0.62±0.25	0.56±0.27	0.78±0.31	0.61±0.28^▲
Abstract ability	0.58±0.31	0.57±0.29	0.60±0.39	0.58±0.35	0.69±0.37	0.59±0.36^□
Delayed memory	2.54±1.22	2.55±1.25	2.79±1.53	2.61±1.48	3.55±1.41	2.87±1.52^■
Orientation	3.24±1.35	3.26±1.32 F =4.311 F =5.719	3.57±1.44 P=0.032* P=0.004**	3.38±1.37	3.86±1.27	3.45±1.33^▽

Notes: *Indicates post-treatment comparison between two groups; **Indicates different time points before and after treatment for comparisons within the test group. The control group received 10 mg of donepezil hydrochloride tablets orally, once a day. The test group was treated with a “cocktail therapy”, which consisted of 10 mg of donepezil hydrochloride tablets taken orally, once a day; 200 mg of dl-3n-butylphthalide soft capsules taken orally, 15 mins before each meal, three times daily; 800 mg of oxiracetam capsules taken orally, three times daily; and 80 mg of Ginkgo biloba extract tablets taken orally, three times daily. ^oF=4.093, p=0.037. ^●F=4.325, p=0.031. ^△F =3.597, p=0.044. ^▲F=5.528, p=0.011. ^□F=3.487, p=0.046. ^■F=5.241, p=0.013. ^▽F=3.4498, p=0.04.

Table 4 Comparison of Blessed-Roth scores in the test and control groups before and after treatment (mean ± SD)

Groups	Cases	Before the treatment	3 months after the treatment	6 months after the treatment
Test group	30	10.19±2.30	9.26±2.19	7.84±2.01
Control group	30	10.27±2.54 F =4.215, P=0.034* F =5.437, P=0.011** F =4.806, P=0.024^#	9.92±2.02	9.17±1.95

Notes: *Indicates post-treatment comparison between two groups; **Indicates different time points before and after treatment for comparisons within the test group; ^#Indicates different time points before and after treatment for comparisons between the two groups. The control group received 10 mg of donepezil hydrochloride tablets orally, once a day. The test group was treated with a “cocktail therapy”, which consisted of 10 mg of donepezil hydrochloride tablets taken orally, once a day; 200 mg of dl-3n-butylphthalide soft capsules taken orally, 15 mins before each meal, three times daily; 800 mg of oxiracetam capsules taken orally, three times daily; and 80 mg of Ginkgo biloba extract tablets taken orally, three times daily.

Table 5 Comparison of CDR-SB scores in the test and control groups before and after treatment (mean ± SD)

Groups	Cases	Before the treatment	3 months after the treatment	6 months after the treatment
Test group	30	4.98±1.24	4.67±1.15	3.91±0.93
Control group	30	4.95±1.29 F =4.189, P=0.035* F =5.038, P=0.015** F =4.457, P=0.03^#	4.87±1.08	4.52±1.02

Notes: *Indicates post-treatment comparison between two groups; **Indicates different time points before and after treatment for comparisons within the test group; ^#Indicates different time points before and after treatment for comparisons between the two groups. The control group received 10 mg of donepezil hydrochloride tablets orally, once a day. The test group was treated with a “cocktail therapy”, which consisted of 10 mg of donepezil hydrochloride tablets taken orally, once a day; 200 mg of dl-3n-butylphthalide soft capsules taken orally, 15 mins before each meal, three times daily; 800 mg of oxiracetam capsules taken orally, three times daily; and 80 mg of Ginkgo biloba extract tablets taken orally, three times daily.

Table 6 Comparison of cases with abnormal liver function in the two groups before treatment

Group	n	Before treatment	At 6 months after the treatment	χ^2	p-value
Test group	30	1	5 (16.67%)	0.11	>0.05
Control group	30	1	4 (13.33%)

Notes: The control group received 10 mg of donepezil hydrochloride tablets orally, once a day. The test group was treated with a “cocktail therapy”, which consisted of 10 mg of donepezil hydrochloride tablets taken orally, once a day; 200 mg of dl-3n-butylphthalide soft capsules taken orally, 15 mins before each meal, three times daily; 800 mg of oxiracetam capsules taken orally, three times daily; and 80 mg of Ginkgo biloba extract tablets taken orally, three times daily.