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Neuropsychiatric Disease and Treatment Volume 15, 2019 - Issue
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Original Research

Neuroprotection by 2,3,5,4ʹ-tetrahydroxystilbene-2-O-β-D-glucoside extracts from Polygonum multiflorum against cerebral ischemia/reperfusion injury through the 5-hydroxytryptamine/5-hydroxytryptamine receptor pathway

Chuan-An Yi1 Department of Pathology, School of Basic Medicine, Central South University, Changsha, Hunan Province, 410008, People’s Republic of China;2 Medical Morphology Experiment Center, Hunan University of Medicine, Huaihua, Hunan Province, People’s Republic of China;3 Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410078, People's Republic of China
,
Jun Wang4 Ningbo No. 7 Hospital, Ningbo, Zhejiang Province315000, People’s Republic of China
,
Ye Wang2 Medical Morphology Experiment Center, Hunan University of Medicine, Huaihua, Hunan Province, People’s Republic of China
&
Xiao-Ying Wu1 Department of Pathology, School of Basic Medicine, Central South University, Changsha, Hunan Province, 410008, People’s Republic of China;3 Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410078, People's Republic of ChinaCorrespondence[email protected]
Pages 1429-1438 | Published online: 27 May 2019

Figures & data

Figure 1 Effects of TSG on infarct size in rats with cerebral ischemia/reperfusion injury. Data are expressed as the mean ± SD (n=3 per group); ##P<0.01 vs control group; *P<0.05, **P<0.01 vs model group.

Abbreviation: TSG, 2,3,5,4ʹ-tetrahydroxystilbene-2-O-β-D-glucoside.
Figure 1 Effects of TSG on infarct size in rats with cerebral ischemia/reperfusion injury. Data are expressed as the mean ± SD (n=3 per group); ##P<0.01 vs control group; *P<0.05, **P<0.01 vs model group.

Figure 2 Expression of uncoupling protein 4 (UCP4) at different stages of cerebral ischemia/reperfusion. (A) Control group (the cortex, ×20); (B) ischemia 6 hours (the hippocampus, ×20); (C)  ischemia 24 hours (the hippocampus, ×20). (D) Western blot analysis of UCP4 expression. *P<0.05 vs control group, **P<0.01 vs control group, n=3.

Abbreviation:  UCP4, uncoupling protein 4.
Figure 2 Expression of uncoupling protein 4 (UCP4) at different stages of cerebral ischemia/reperfusion. (A) Control group (the cortex, ×20); (B) ischemia 6 hours (the hippocampus, ×20); (C)  ischemia 24 hours (the hippocampus, ×20). (D) Western blot analysis of UCP4 expression. *P<0.05 vs control group, **P<0.01 vs control group, n=3.

Figure 3 Effects of TSG on uncoupling protein 4 (UCP4) expression in rats with cerebral ischemia/reperfusion injury. Data are expressed as the mean ± SD (n=3 per group); ##P<0.01 vs control group; *P<0.05, **P<0.01 vs model group.

Abbreviation: TSG, 2,3,5,4ʹ-tetrahydroxystilbene-2-O-β-D-glucoside; UCP4, uncoupling protein 4.
Figure 3 Effects of TSG on uncoupling protein 4 (UCP4) expression in rats with cerebral ischemia/reperfusion injury. Data are expressed as the mean ± SD (n=3 per group); ##P<0.01 vs control group; *P<0.05, **P<0.01 vs model group.

Figure 4 Effects of TSG on 5-hydroxytryptamine (5-HT) content in rats with cerebral ischemia/reperfusion injury. Data are expressed as the mean ± SD (n=3 per group); ##P<0.01 vs control group; *P<0.05, **P<0.01 vs model group.

Abbreviation: TSG, 2,3,5,4ʹ-tetrahydroxystilbene-2-O-β-D-glucoside; 5-HT, 5-hydroxytryptamine.
Figure 4 Effects of TSG on 5-hydroxytryptamine (5-HT) content in rats with cerebral ischemia/reperfusion injury. Data are expressed as the mean ± SD (n=3 per group); ##P<0.01 vs control group; *P<0.05, **P<0.01 vs model group.

Figure 5 Effects of TSG on 5-hydroxytryptamine transporter (5-HTT) expression in rats with cerebral ischemia/reperfusion injury. Data are expressed as the mean ± SD (n=3 per group); ##P<0.01 vs control group; *P<0.05, **P<0.01 vs model group.

Abbreviation: TSG, 2,3,5,4ʹ-tetrahydroxystilbene-2-O-β-D-glucoside; 5-HTT, 5-hydroxytryptamine transporter.
Figure 5 Effects of TSG on 5-hydroxytryptamine transporter (5-HTT) expression in rats with cerebral ischemia/reperfusion injury. Data are expressed as the mean ± SD (n=3 per group); ##P<0.01 vs control group; *P<0.05, **P<0.01 vs model group.

Figure 6 Effects of TSG on 5-hydroxytryptamine receptor 2A (5-HT2A) expression in rats with cerebral ischemia/reperfusion injury. (A) Control group (the thalamic nucleus, ×40); (B) Model group (the thalamic nucleus, ×40); (C) TSG group (the thalamic nucleus, ×40). (D) Western blot analysis of 5-HT2A expression. Data are expressed as the mean ± standard deviation (n=3 per group); ##P<0.01 vs control group; *P<0.05, **P<0.01 vs model group.

Abbreviation: TSG, 2,3,5,4ʹ-tetrahydroxystilbene-2-O-β-D-glucoside; 5-HT2A, 5-hydroxytryptamine receptor 2A.
Figure 6 Effects of TSG on 5-hydroxytryptamine receptor 2A (5-HT2A) expression in rats with cerebral ischemia/reperfusion injury. (A) Control group (the thalamic nucleus, ×40); (B) Model group (the thalamic nucleus, ×40); (C) TSG group (the thalamic nucleus, ×40). (D) Western blot analysis of 5-HT2A expression. Data are expressed as the mean ± standard deviation (n=3 per group); ##P<0.01 vs control group; *P<0.05, **P<0.01 vs model group.

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