Gabapentin enacarbil for antipsychotic induced akathisia in schizophrenia patients: a pilot open-labeled study

Figures & data

Table 1 Clinical and demographic characteristics

Age (years)	Sex	GE dosage (mg/day)	Causative agent of akathisia and dosage	Period from akathisia onset to study (weeks)	Concomitant drug with therapeutic potential for akathisia
42	F	600	APZ (30 mg/day)	2	Diazepam (15 mg/day)
37	M	600	RIS (6 mg/day)	3	Biperiden (2 mg/day)
40	F	600	CLZ (600 mg/day)	2	Biperiden (1 mg/day) and diazepam (15 mg/day)
27	F	600	APZ (30 mg/day)	3	Etizolam (3 mg/day) and bromazepam (15 mg/day)
52	F	300	PER (40 mg/day)	4	Propranolol (20 mg/day), biperiden (2 mg/day), diazepam (4 mg/day), and clonazepam (0.5 mg/day)
20	F	600	PAL LAI (150 mg/4 weeks)	1	None
44	F	600	APZ LAI (400 mg/4 weeks)	2	None
55	M	600	APZ (6 mg/day)	3	None
37	F	600	APZ (24 mg/day)	2	Diazepam (4 mg/day)

Abbreviations: APZ, aripiprazole; CLZ, clozapine; F, female; GE, gabapentin enacarbil; LAI, long-acting injection; M, male; PAL, paliperidone; PER, perospirone; RIS, risperidone.

Table 2 Changes in symptom evaluation scores during the study

Case	BARS global akathisia score			BPRS score
	0 week	1 week	2 weeks	0 week	1 week	2 weeks
1	3	1	1	41	34	32
2	3	2	1	47	47	47
3	3	2	2	46	35	35
4	3	2	1	48	48	46
5	4	2	0	39	37	37
6	3	2	1	34	33	32
7	4	4	4	31	31	31
8	4	1	0	38	38	38
9	3	1	0	40	38	38

Abbreviations: BARS, Barnes Akathisia Rating Scale; BPRS, Brief Psychiatric Rating Scale.

Figure 1 Changes in the BARS global akathisia score.

Notes: Compared with BARS global akathisia score at the baseline, global akathisia score at week 1 and 2 significantly decreased (P=0.01, P=0.01, respectively). Between the BARS global akathisia scores at week 1 and 2, significant difference was not observed. Error bars indicate standard error. *Significant difference between baseline and 1 week after treatment onset (P<0.016). ^#Significant difference between baseline and 2 weeks after treatment onset (P<0.016).
Abbreviation: BARS, Barnes Akathisia Rating Scale.

Figure 2 Changes in BPRS scores.

Notes: Any significant difference was not found on BPRS scores in post hoc analyses. Error bars indicate standard error.
Abbreviation: BPRS, Brief Psychiatric Rating Scale.