Aripiprazole for the treatment of psychotic symptoms in patients with dementia with Lewy bodies: a case series

Figures & data

Table 1 Patients’ aripiprazole doses

Case	Dose of aripiprazole (mg/day)
	Baseline	1 week	2 weeks	4 weeks	8 weeks	10 weeks
1	6	6	12	12	12	12
2	3	3	6	9	12	12
3	3	3	6	6	9	9
4	3	3	6	9	12	12
5	3	3	6	–	–	–
6	3	3	6	6	6	6
7	3	3	6	6	6	6
8	6	6	12	12	12	12
9	6	6	12	12	12	12
10	3	3	–	–	–	–
11	6	6	12	12	12	12
Mean	4.1	4.1	8.4	9.3	10.3	10.3

Figure 1 Mean NPI, BPRS, and CGI-S scores of the patients who completed the study.

Notes: *Significantly decreased compared to baseline (P<0.01). ^**Significantly decreased compared to previous assessment point (P<0.01).
Abbreviations: BPRS, Brief Psychiatric Rating Scale; CGI-S, Clinical Global Impression-Severity; NPI, Neuropsychiatric Inventory.

Table 2 Patient characteristics

Case	Sex	Age (years)	Category of DLB	Stage	Concomitant medication	Complication of mental illness	Inpatient/outpatient
1	F	78	Probable	Moderate	Valproic acid	MDI	Inpatient
2	F	65	Probable	Severe	Clonazepam	RBD	Outpatient
3	F	84	Probable	Moderate	Benzodiazepine	D	Outpatient
4	M	83	Probable	Moderate	Clonazepam	RBD	Outpatient
5	F	83	Probable	Moderate	–	MDI	Outpatient
6	F	75	Probable	Moderate	–	–	Outpatient
7	F	78	Probable	Severe	–	–	Outpatient
8	M	73	Probable	Moderate	Maprotiline	D	Inpatient
9	F	72	Probable	Moderate	Benzodiazepine	MDI	Inpatient
10	F	75	Probable	Severe	–	–	Inpatient
11	F	74	Probable	Moderate	–	MDI	Inpatient

Note: Stage, based on baseline MMSE scale (severe, 0–9; moderate, 10–19; mild, 20–23).

Abbreviations: D, depression; DLB, dementia with Lewy bodies; F, female; M, male; MDI, manic-depressive illness; MMSE, Mini-mental State Examination; RBD, rapid eye movement sleep behavior disorder.

Table 3 Median SAS, CDR, and MMSE scores (range) of the patients who completed the study

Measure	Baseline	10 weeks	P-value
SASa	9 (4–14)	6 (4–9)	<0.05
CDRa	2 (1–3)	1 (1–2)	NS
MMSEa	15 (9–19)	17 (12–21)	<0.05

Note:

a Wilcoxon signed-rank test.

Abbreviations: CDR, Clinical Dementia Rating; MMSE, Mini-mental State Examination; NS, not significant; SAS, Simpson–Angus Scale.