Serum BICC1 levels are significantly different in various mood disorders

Figures & data

Table 1 Demographic and clinical characteristics of participants

Variable	MDD	BM	BD	HC	F/χ^2/Z	P-value
Sex, male/female, n (total N)	13/17 (N =30)	15/15 (N= 30)	7/6 (N=13)	15/15 (N= 30)	0.518	0.915a
Age (years)	37.40±11.63	32.80±10.82	33.92±15.48	35.10±9.14	0.991	0.400b
Age of onset (years)	33.30±12.09	24.47±7.88#	24.15±10.16#	–	6.778	0.002b
BMI (kg/m^2)	22.45±3.40	22.42±3.18	24.01±4.00	23.08±2.95	0.512	0.675b
Episodes	1.70±1.62	3.77±1.68#	3.31±1.03#	–	13.880	0.000b
Marital status					3.244	0.356a
Single, n	7	9	6	7
Married, n	22	20	6	21
Divorced/widow, n	1	1	1	2
Duration of illness (years)	4.15±8.12	8.33±7.74	9.58±11.28	–	2.457	0.093b
Family history of psychosis, yes/no	4/26	7/23	7/6	–	7.951	0.019a
HDRS score	23.53±3.82*	–	14.47±11.26*	1.60±1.00	52.837	0.000d
YMRS score	–	30.40±10.48*	–	0.67±0.71	−6.726	0.000c

Notes:

a Chi-squared test.

b One-way ANOVA.

c Mann–Whitney U test.

d Kruskal–Wallis H test.

* P<0.05 compared with the HC group.

# P<0.05 compared with the MDD group.

Abbreviations: BD, bipolar depression; BM, bipolar mania; BMI, body mass index; HC, healthy controls; HDRS, 17-item Hamilton Depression Rating Scale; MDD, major depressive disorder; YMRS, Young Mania Rating Scale.

Figure 1 Serum levels of BICC1 in patients with different types of mood disorders and HC.

Notes: Compared with HC: *P_Tukey <0.05 and **P_Tukey <0.001; compared with BD: &&P_Tukey <0.001; compared with BM: ^$$P_Tukey <0.001.
Abbreviations: BD, bipolar depression; BM, bipolar mania; HC, healthy controls; MDD, major depressive disorder.

Figure 2 Diagnostic and differential powers of serum BICC1.

Note: ROC curves of BICC1 between: (A) MDD and HC, (B) BM and HC, (C) BD and HC, (D) MDD and BD, (E) BM and BD, and (F) MDD and BM.
Abbreviations: AUC, area under the curve; BD, bipolar depression; BM, bipolar mania; HC, healthy controls; MDD, major depressive disorder; ROC, receiver operating characteristic.

Table 2 Results of ROC curve analysis among these four groups

Comparison	Sensitivity	Specificity	AUC	Cutoff (pg/mL)	95% CIa	P-value
MDD vs HC	1.000	0.767	0.954	569.750	0.910–0.999	<0.001
BM vs HC	0.367	1.000	0.714	623.050	0.582–0.847	0.004
BD vs HC	1.000	1.000	1.000	668.505	1.000–1.000	<0.001
MDD vs BD	1.000	1.000	1.000	712.710	1.000–1.000	<0.001
BM vs BD	1.000	1.000	1.000	702.790	1.000–1.000	<0.001
MDD vs BM	1.000	0.533	0.787	569.460	0.673–0.901	<0.001

Note:

a 95% CI for AUC.

Abbreviations: AUC, area under the curve; BD, bipolar depression; BM, bipolar mania; HC, healthy controls; MDD, major depressive disorder; ROC, receiver operating characteristic.