The association between CD157/BST1 polymorphisms and the susceptibility of Parkinson’s disease: a meta-analysis

Figures & data

Table 1 Characteristics of included studies

Reference	Year	Ethnicity/location	Case	Control	Genotyping methods	Age (mean±SD), case/control	Female %, case/control	HWE	SNPs	NOS
Chang et al^Citation22	2011	Chinese	636	510	Massarray	55.83±11.18/ 52.44±14.01	40.6%/43.1%	P>0.05	rs11931532; rs4698412; rs11724635	7
Miyake et al^Citation28	2012	Japanese	229	357	TaqMan	68.4±8.7/ 66.6±8.5	61.6%/61.1%	P>0.05	rs11931532; rs11724635	8
Chang et al^Citation23	2015	Chinese	596	597	Agena Massarray	68.68±10.82/60.0±12.7	45.9%/54.4%	P>0.05	rs11724635	7
Cui et al^Citation26	2018	Chinese	168	196	Massarray	68.82±10.70/ 67.35±5.51	41.7%/45.4%	P>0.05	rs11931532; rs4698412	6
Tian^Citation31	2012	Chinese	1,019	1,030	Sequencing	54.16±12.50/ 52.16±16.45	41.5%/47.6%	P>0.05	rs11931532; rs4698412	7
Satake et al [1]^Citation20	2011	Japanese	1,078	2,628	HumanHap550 array	NA	NA	P>0.05	rs11931532; rs4698412	6
Satake et al [2]^Citation20	2011	Japanese	988	2,521	HumanHap550 array	NA	NA	P>0.05	rs11931532; rs4698412	6
Tan et al^Citation10	2010	Chinese	433	916	Massarray	NA	44%/40%	P>0.05	rs11931532; rs4698412	6
Simón-Sánchez et al^Citation25	2011	the Netherlands	772	2,024	Human660W-Quad array	57.5±12.0/ 53.75±13.4	39.9%/53.6%	P>0.05	rs11931532; rs4698412	8
Spencer et al^Citation8	2011	UK	2,190	5,667	Human660-Quad array	NA	27.0%/NA	P>0.05	rs4698412	6
Xie^Citation32	2011	Chinese	744	743	Sequencing	53.05±10.9/ 52.34±12.1	36.7%/41.6%	P>0.05	rs4698412	6
Chen et al^Citation27	2014	Chinese	468	487	TaqMan	66.02±9.46/ 67.16±9.33	49.8%/66.5%	P>0.05	rs11724635	8

Abbreviations: HWE, Hardy-Weinberg equilibrium; SNP, single nucleotide polymorphism; NOS, Newcastle-Ottawa scale; NA, not available.

Figure 1 PRISMA flow chart of studies included and excluded.

Table 2 The association between BST1 polymorphisms and Parkinson’s disease

SNPs (minor allele)	Genetic model	Subgroup	Number of studies	Numbers		Test of association		Model	Test of heterogeneity
				Case	Control	OR [95% CI]	P-value		P-value	I^Citation2 (%)
rs11931532 (T)	Allelic (T)	Total	8	10,646	20,364	1.24 [0.86–1.78]	0.25	R	<0.00001	98
		Asian	7	9,102	16,316	1.28 [0.86–1.88]	0.22	R	<0.00001	98
		Caucasian	1	1,544	4,048	1.00 [0.71–1.41]	0.25	–	–	–
	Dominant (TT+CT/CC)	Total	4	2,052	2,093	1.22 [1.06–1.41]	0.006	F	0.77	0
		Asian	4	2,052	2,093	1.22 [1.06–1.41]	0.006	F	0.77	0
		Caucasian	0	–	–	–	–	–	–	–
	Recessive (TT/CT+CC)	Total	4	2,052	2,093	1.05 [0.91–1.22]	0.47	F	0.31	17
		Asian	4	2,052	2,093	1.05 [0.91–1.22]	0.47	F	0.31	17
		Caucasian	0	–	–	–	–	–	–	–
rs4698412 (A)	Allelic (A)	Total	9	16,056	32,470	1.16 [1.08–1.25]	<0.0001	R	0.003	65
		Asian	7	10,132	17,008	1.22 [1.16–1.29]	<0.00001	F	0.43	0
		Caucasian	2	5,924	15,382	1.03 [0.92–1.16]	0.62	R	0.08	67
	Dominant (AA+GA/GG)	Total	4	2,576	2,479	1.35 [1.20–1.52]	<0.00001	F	0.67	0
		Asian	4	2,576	2,479	1.35 [1.20–1.52]	<0.00001	F	0.67	0
		Caucasian	0	–	–	–	–	–	–	–
	Recessive (AA/GA+GG)	Total	4	2,576	2,479	1.30 [1.13–1.50]	0.0003	F	0.44	0
		Asian	4	2,576	2,479	1.30 [1.13–1.50]	0.0003	F	0.44	0
		Caucasian	0	–	–	–	–	–	–	–
rs11724635 (A)	Allelic (A)	Total	3	2,586	2,882	1.07 [0.96–1.20]	0.19	F	0.34	7
		Asian	3	2,586	2,882	1.07 [0.96–1.20]	0.19	F	0.34	7
	Dominant (AA+CA/CC)	Total	3	1,293	1,441	1.08 [0.92–1.27]	0.33	F	0.56	0
		Asian	3	1,293	1,441	1.08 [0.92–1.27]	0.33	F	0.56	0
	Recessive (AA/CA+AA)	Total	3	1,293	1,441	1.12 [0.92–1.37]	0.25	F	0.42	0
		Asian	3	1,293	1,441	1.12 [0.92–1.37]	0.25	F	0.42	0

Abbreviations: SNP, single nucleotide polymorphism; R, random model; F, fixed model; OR, odds ratios; CIs, confidence intervals.

Figure 2 Forest plots of odds ratios for the association between BST1 rs11931532 and PD. (A) allelic model; (B) dominant model; (C) recessive model.

Abbreviation: PD, Parkinson’s disease.

Figure 3 Forest plots of odds ratios for the association between BST1 rs4698412 and PD. (A) allelic model; (B) dominant model; (C) recessive model.

Abbreviation: PD, Parkinson’s disease.

Figure 4 Forest plots of odds ratios for the association between BST1 rs11724635 and PD. (A) allelic model; (B) dominant model; (C) recessive model.

Abbreviation: PD, Parkinson’s disease.

Figure 5 Sensitivity analyses between allelic models of BST1 rs11931532, rs4698412, rs11724635, and PD. (A) rs11931532; (B) rs4698412; (C) rs11724635.

Abbreviation: PD, Parkinson’s disease.

Figure 6 Publication bias of literatures for BST1 rs11931532, rs4698412, and rs11724635 were tested by Begg’ s funnel plot and Egger’ s test. (A) rs11931532; (B) rs4698412; (C) rs11724635.

Abbreviations: BST1, bone marrow stromal cell antigen 1.

Table S1 Methodological quality of the included studies according to the Newcastle-Ottawa scale

Reference	Year	Ethnicity/location	Adequacy of case definition	Representative ness of the cases	Selection of controls	Definition of controls	Comparability cases/controls	Ascertainment of exposure	Same method of ascertainment	Non-response rate	Total
Chang	2011	Chinese	*	*	*	NA	*	*	*	NA	7
Miyake	2012	Japanese	*	*	*	NA	*	*	*	*	8
Chang	2015	Chinese	*	*	*	NA	*	*	*	NA	7
Cui	2018	Chinese	*	*	*	NA	*	*	*	*	8
Tian	2012	Chinese	*	*	*	NA	*	*	*	NA	7
Satake	2011	Japanese	NA	NA	*	*	*	*	*	NA	6
Tan	2010	Chinese	NA	NA	*	*	*	*	*	NA	6
Simón-Sánchez	2011	the Netherlands	*	*	*	*	*	*	NA	*	8
Spencer	2011	UK	NA	NA	*	NA	*	*	*	*	6
Xie	2011	Chinese	NA	NA	*	*	*	*	NA	*	6
Chen	2014	Chinese	*	*	*	NA	*	*	*	*	8

Notes: This table identifies high quality choices with “an asterisk.” A study can be awarded a maximum of one star for each numbered item within the Selection and Exposure categories. A maximum of two stars can be given for Comparability.

Abbreviations: *, Yes; NA, not applicable.

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