The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse

Figures & data

Table 1 The demographic and clinical characteristics of alcohol-dependent patients

Alcohol-dependent patients	Patients with early onset of alcohol abuse 215 (35.07%)	Patients with late onset of alcohol abuse 398 (64.93%)	Total 613 (100.00%)	Statistics
Age (years) mean ± SD	45.12±10.09	52.33±9.46	49.80±10.27	t=8.79, df =611, P<0.0001; Student’s t-test
Smokers, N (%)	145 (67.44%)	225 (56.53%)	370 (60.36%)	χ^2=6.943, df =1, P=0.0084; χ^2-test
Nonsmokers, N (%)	70 (32.56%)	173 (43.47%)	243 (39.64%)
Males, N (%)	193 (38.68%)	306 (61.32%)	499 (81.40%)	χ^2=15.30, df =1, P<0.0001; χ^2-test
Females, N (%)	22 (19.30%)	92 (80.70%)	114 (18.60%)
Patients with somatic comorbidities, N (%)	128 (59.53%)	267 (67.08%)	395 (64.44%)	χ^2=3.473, df =1, P=0.0624; χ^2-test
Patients with liver disease, N (%)	125 (58.14%)	261 (65.58%)	386 (62.97%)	χ^2=3.312, df =1, P=0.0688; χ^2-test
Patients with psychiatric comorbidities, N (%)	112 (52.09%)	167 (41.96%)	279 (45.51%)	χ^2=5.780, df =1, P=0.0162; χ^2-test
Patients with depression, N (%)	10 (4.65%)	24 (6.03%)	34 (5.55%)	χ^2=0.5067, df =1, P=0.4766; χ^2-test
Platelet 5-HT concentration (nmol/mg protein) mean ± SD	0.88±0.48	0.79±0.48	0.82±0.48	U=38035, df =611, P=0.023; Mann–Whitney test

Table 2 Genotype and allele counts and frequencies of rs13212041 HTR1B gene polymorphism in alcohol-dependent patients subdivided according to the gender and early/late onset of alcohol abuse

HTR1B SNP	Genotype N (%)			Statistics	Allele N (%)		Statistics
rs13212041	CC	CT	TT	df =2	C	T	df =1
Males, N (%)	21 (4.21)	157 (31.46)	321 (64.33)	χ^2=2.135, P=0.344; χ^2-test	199 (19.94)	799 (80.06)	χ^2=1.977, P=0.160; χ^2-test
Females, N (%)	6 (5.26)	43 (37.72)	65 (57.02)		55 (24.12)	173 (75.88)
Early onset of alcohol abuse, N (%)	16 (7.44)	65 (30.23)	134 (62.33)	χ^2=7.539, P=0.023; χ^2-test	97 (22.56)	333 (77.44)	χ^2=1.366, P=0.243; χ^2-test
Late onset of alcohol abuse, N (%)	11 (2.76)	135 (33.92)	252 (63.32)		157 (19.72)	639 (80.28)

Figure 1 Platelet 5-HT concentration in alcohol-dependent smokers and nonsmokers subdivided according to the early/late onset of alcohol abuse.

Note: *P<0.0005 smokers vs nonsmokers (Kruskal–Wallis test and post-hoc Dunn’s multiple comparison test).