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Neuropsychiatric Disease and Treatment Volume 15, 2019 - Issue
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Original Research

Repetitive transcranial magnetic stimulation as an adjunctive treatment for negative symptoms and cognitive impairment in patients with schizophrenia: a randomized, double-blind, sham-controlled trial

Kaiming Zhuo1 First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Yingying Tang1 First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;2 Department of EEG and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Zhenhua Song1 First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Yingchan Wang1 First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Junjie Wang2 Department of EEG and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Zhenying Qian2 Department of EEG and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Hui Li2 Department of EEG and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Qiong Xiang1 First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Tianyi Chen1 First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;3 Shanghai Hong Kou Mental Health Center, Shanghai, People’s Republic of China
,
Zhilei Yang1 First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;4 Shanghai Jia Ding Mental Health Center, Division of Psychotic Disorders, Shanghai, People’s Republic of China
,
Yifeng Xu1 First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;5 Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Xiaoduo Fan6 Psychotic Disorders Program, UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, MA, USA
,
Jijun Wang1 First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;2 Department of EEG and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;5 Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
&
Dengtang Liu1 First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;5 Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 1141-1150 | Published online: 08 May 2019

Figures & data

Table 1 The demographic and clinical characteristic of the two groups

Figure 1 The study flow chart.

Abbreviation: rTMS, repetitive transcranial magnetic stimulation.

Figure 1 The study flow chart.Abbreviation: rTMS, repetitive transcranial magnetic stimulation.

Table 2 Comparison of the symptoms changes pre- and post-treatment between the two study groups

Figure 2 Scores for severity of symptoms during the trail. Data appear mean ± SD in blue for active rTMS and in red for sham rTMS.

Notes: Patients in the active rTMS group had a great improvement in SANS total score and PANSS negative subscore after 4-week treatment (A and D). However, there were no significant differences in PANSS total score and positive subscore between the active and sham rTMS group (B and C).

Abbreviation: rTMS, repetitive transcranial magnetic stimulation.
Figure 2 Scores for severity of symptoms during the trail. Data appear mean ± SD in blue for active rTMS and in red for sham rTMS.Notes: Patients in the active rTMS group had a great improvement in SANS total score and PANSS negative subscore after 4-week treatment (A and D). However, there were no significant differences in PANSS total score and positive subscore between the active and sham rTMS group (B and C).

Table 3 Comparison of MCCB changes pre- and post-treatment between the two study groups

Table 4 Results of the stepwise multiple regression analyses in patients

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