Thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study

Figures & data

Table 1 Demographic and clinical characteristics of the study subjects (mean ± SD)

	Manic group n=28	Depressive group n=58	P-value*
Gender (n, male/female)	15/13	31/27	0.992
Age (years)	29.5±8.9	20.7±6.7	<0.001
Height (centimeter)	167.6±10.2	167.6±8.1	0.984
Weight (kilogram)	63.13±14.1	60.93±15.2	0.530
BMI (kg/m^2)	22.26±3.37	21.51±4.20	0.419
Total disease course (month)	31.02±28.87	48.02±61.77	0.128
Duration of current episode (day)	23.81±22.91	137.61±211.98	0.004

Note: *Significant at P<0.05 (two-tailed).

Abbreviation: SD, standard deviation.

Table 2 Compassion of baseline thyroid profiles in patients with manic and depressive episodes (mean ± SD)

	Manic group n=28	Depressive group n=58	Reference range	P-value*
TT4 (nmol/L)	97.18±24.09	96.02±18.30	55.47~161.25	0.823
TT3 (nmol/L)	1.48±0.36	1.52±0.30	1.02~2.96	0.619
TSH (mU/L)	1.50±0.62	1.53±1.02	0.38~4.34	0.893
FT4 (pmol/L)	15.55±3.50	16.27±2.59	10.45~24.38	0.287
FT3 (pmol/L)	4.72±0.70	4.96±0.74	2.77~6.31	0.154

Note: *Significant at P<0.05 (two-tailed).

Abbreviation: SD, standard deviation; TT4, total thyroxine; TT3,  total triiodothyronine; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid-stimulating hormone.

Table 3 Changes of scale scores before and after one-month quetiapine treatment in depressed patients with bipolar disorder (mean ± SD)

	Baseline n=58	Post-treatment n=58	P-value*
HAMD-24	29.63±9.89	13.88±10.12	<0.001
HAMA	22.09±8.17	11.18±8.24	<0.001

Note: *Significant at P<0.05 (two-tailed).

Abbreviations: SD, standard deviation; HAMD-24, 24-item Hamilton Depression Rating Scale; HAMA, Hamilton Anxiety Rating Scale.

Figure 1 Changes of thyroid indices before and after one-month quetiapine treatment in depressed patients with bipolar disorder (n=58).

Abbreviations: TT4, total thyroxine; TT3, total triiodothyronine; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid-stimulating hormone.

Figure 2 Changes of thyroid indices before and after one- or three-mouth quetiapine treatment in depressed patients with bipolar disorder (n=13).

Abbreviations: TT4, total thyroxine; TT3, total triiodothyronine; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid-stimulating hormone.