Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease

Figures & data

Table 1 Demographic data of alzheimer’s disease patients

Alzheimer’s disease patients (n=255)
	Mean	SD
Age, years	80	8.0
Female, n	130	65.3
CDR, n (%)
0.5	70 (27.5)
1	128 (50.0)
2	52 (20.0)
3	5 (2.5)
APOE e4, n (%)	74 (29)
Education, years	7	4.8
MMSE	16.6	6.1

Abbreviation: CDR, clinical dementia rating assignment.

Table 2 Adjusted factors contributing to the development of EPS in alzheimer’s disease patients

	OR	95% CI	p
Age	1.05	0.96–1.14	0.303
Gender	0.75	0.21–2.69	0.655
APOE e4	4.515	1.12–18.15	0.034
Initial dementia stage (CDR)
0.5	1
1	1.11	0.25–4.96	0.891
≥2	1.73	0.34–8.72	0.506

Abbreviation: CDR, clinical dementia rating.

Figure 1 Kaplan-Meier survival curve of AD developing EPS. Log rank test (t=8.14, p=0.004).

Abbreviations: APOE, Apolipoprotein E; AD, Alzheimer’s disease.