Comparative diagnostic accuracy of ACE-III and MoCA for detecting mild cognitive impairment

Figures & data

Table 1 Clinical and demographic characteristics (mean ± SD)

	MCI (n=120)	Control (n=136)	p-value
Age, years	76.87±7.87	69.24±11.41	<0.05
Male, %	54.17	54.41	>0.05
Education, years	11.31±3.23	14.29±2.50	<0.05
MMSE score	25.60±1.94	28.58±1.29	<0.05
MoCA total score	20.19±3.06	26.51±2.08	<0.05
MoCA delayed recall score	1.19±1.39	3.22±1.44	<0.05
ACE-III total score	73.48±8.87	91.34±4.66	<0.05
ACE-III orientation/attention score	16.34±1.57	17.54±0.75	<0.05
ACE-III memory score	19.36±4.75	24.35±1.71	<0.05
ACE-III language score	18.47±3.81	23.71±1.95	<0.05
ACE-III verbal fluency score	7.61±2.42	10.61±2.04	<0.05
ACE-III visuospatial score	12.08±3.30	15.29±0.098	<0.05

Abbreviations: MCI, mild cognitive impairment; MMSE, mini-mental state examination; MoCA, Montreal Cognitive Assessment; ACE-III, Addenbrooke’s Cognitive Examination III.

Table 2 Correlations between tests

	MoCA total score		MoCA delayed recall score		MMSE score
	r	p	r	p	r	p
ACE-III total score	0.794	<0.05	–	–	0.759	<0.05
ACE-III orientation/attention score	0.483	<0.05	–	–	–	–
ACE-III memory score	0.563	<0.05	0.517	<0.05	–	–
ACE-III language score	0.641	<0.05	–	–	–	–
ACE-III verbal fluency score	0.610	<0.05	–	–	–	–
ACE-III visuospatial score	0.625	<0.05	–	–	–	–
MoCA total score	-	-	–	–	0.642	<0.05
MMSE score	0.642	0.000	–	–	–	–

Abbreviations: MMSE, mini-mental state examination; MoCA, Montreal Cognitive Assessment; ACE-III, Addenbrooke’s Cognitive Examination III.

Table 3 Sensitivity, specificity, optimal cutoff point, and Area Under ROC Curve (AUC) of tests

	Youden index	Sensitivity (%)	Specificity (%)	Optimal cut-off point	AUC
MMSE score	0.655	83.8	81.7	≤28	0.891
MoCA total score	0.853	97.8	87.5	≤23	0.965
MoCA delayed recall score	0.612	77.9	83.3	≤3	0.830
ACE-III total score	0.887	91.2	97.5	≤85	0.980
ACE-III orientation/attention score	0.420	66.2	24.2	≤18	0.752
ACE-III memory score	0.505	77.2	73.1	≤24	0.844
ACE-III language score	0.588	84.6	74.2	≤22	0.876
ACE-III verbal fluency score	0.471	52.9	94.2	≤11	0.824
ACE-III visuospatial score	0.532	82.4	70.8	≤15	0.826

Abbreviations: ACE-III, Addenbrooke’s Cognitive Examination III; MoCA, Montreal Cognitive Assessment; MMSE, mini-mental state examination.

Figure 1 Receiver operating characteristic (ROC) curve of tests.