Clinical and Neurocognitive Predictors of Functional Outcome in Depressed Patients with Partial Response to Treatment: One Year Follow-Up Study

Figures & data

Table 1 Sociodemographic and Clinical Characteristics of MDD Patients

	Patients (n = 31)
Age; mean (SD)	54.71 (12.04)
MMSE baseline, mean (SD)	25.31 (4.30)
HDRS baseline mean (SD)	22.55 (7.38)
BDI baseline, mean (SD)	33.29 (11.91)
Scholar, years	8.77 (3.73)
Sex, n (%)
Male	8 (25.8)
Female	23 (74.2)
Antidepressant therapy, n (%)
SSRI	22 (71)
SNRI	9 (29)

Table 2 Correlations Between Baseline Cognitive Variables and Total FAST Score

	FAST	p	p*
MMSE_T0	−0.42	0.02	0.18
MOCA_T0	−0.48	0.01	0.06
FAB_T0	−0.39	0.03	0.26
SPAN_F_T0	−0.46	0.01	0.08
SPAN_B_T0	−0.43	0.02	0.14
REY_I_T0	−0.66	0.00	0.00
REY_D_C_T0	−0.23	0.22	1.00

Notes: *After Bonferroni correction. Bold values indicate statistical significance.

Table 3 Multiple Regression Analysis Between Cognitive Tests and FAST at 1 Year of Follow-Up

	Autonomy		Financial		Interpersonal		Leisure
	R^2 0.47		R^2 0.41		R^2 0.27		R^2 0.29
	Std. Coeff.	p-value	Std. Coeff.	p-value	Std. Coeff.	p-value	Std. Coeff.	p-value
MOCA	−.12	.65	.36	.19	.18	.55	.50	.10
SPAN_F	−.26	.23	−.41	.07	−.02	.93	−.21	.37
REY_I	−.58	.002	−.57	.005	−.41	.05	−.62	.01

Figure 1 Plot of the relationship between Rey immediate recall scores (Rey-I) and FAST.

Table 4 Multiple Regression Analysis Between Improvement in Cognitive Tests and FAST at 1 Year of Follow-Up (T1-T0)

	Autonomy		Interpersonal		Leisure		Cognitive		Total
	R^2 0.18		R^2 0.30		R^2 0.24		R^2 0.47		R^2.0.37
	Std. Coefficient	p-value	Std. Coefficient	p-value	Std. Coefficient	p-value	Std. Coefficient	p-value	Std. Coefficient	p-value
FAB (T1-T0)	0.98	0.58	0.27	0.10	0.19	0.28	0.41	0.01	0.29	0.06
SPAN_F (T1-T0)	0.35	0.06	0.39	0.03	0.46	0.01	0.41	0.01	0.40	0.02
REY_I (T1-T0)	0.01	0.94	0.27	0.12	−0.04	0.84	0.31	0.02	0.28	0.09