Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients

Figures & data

Table 1 Detailed Clinical Data of Each Patient with DR

Series	Gender	Age	DM Type	Grades of DR	Duration of DM (years)	HbA1c (%)	MMSE	Pre-Admission Treatment
1	f	62	2	0	11	7	18	Novo30R+Sitagliptin
2	m	65	2	0	10	14.6	23	Glipizide
3	f	62	2	0	8	8.5	28	Metformin+Sulfonylurea
4	m	72	2	0	15	10.8	29	Acarbose
5	m	51	2	2	10	9.3	25	Acarbose+Repaglinide
6	f	39	2	2	10	9.2	29	Novo30R
7	f	48	2	1	6	9.6	29	Levovir25
8	m	54	2	4	10	9.89	21	Untreated
9	m	61	2	1	17	6.8	27	Novo30R
10	f	49	2	1	2	5.9	25	Novo30R+Metformin
11	f	50	2	1	1	16.8	19	Levovir25
12	f	76	2	3	16	12.2	25	Levovir25+Acarbose
13	m	51	2	0	16	5.8	25	Metformin+Sulfonylurea
14	m	45	2	3	7	7.8	25	Acarbose+Sulfonylurea
15	m	43	2	0	2	12.2	28	Levovir25+Acarbose
16	f	62	2	2	10	10.7	29	Levovir25
17	m	60	2	0	12	10.6	26	Metformin+Repaglinide
18	f	56	2	0	2	6.2	27	Untreated
19	m	50	2	0	5	11.1	29	Glargine+Sitagliptin
20	f	50	2	1	10	6.5	26	Novo30R
21	f	68	2	0	10	8.2	27	Metformin+Sulfonylurea

Table 2 The Connection Strength of Brain Networks and Its P-Value Among Different Brain Regions Between Healthy Controls and DR Patients

Connected Brain Regions	Connection Strength	P-value
Heschl_L-ParaHippocampal_L	0.182	0.003
Heschl_L-Amygdala_L	0.213	0.001
Heschl_L-Amygdala_R	0.213	0.008
Heschl_L-Cuneus_L	0.201	0.007
Heschl_L-Occipital_Sup_L	0.175	0.004
Heschl_L-Occipital_Mid_L	0.186	0.009
Heschl_L-Occipital_Inf_L	0.178	0.005
Heschl_L-Fusiform_L	0.228	0.010
Heschl_L-Parietal_Sup_L	0.221	0.002
Heschl_R-Amygdala_L	0.241	0.002
Heschl_R-Fusiform_L	0.231	0.006
Heschl_R-Fusiform_R	0.233	0.005

Table 3 The Connection Strength of Brain Networks and Its P-Value Among Different Brain Regions Between Healthy Controls and DR Patients

Connected Brain Regions	Connection Strength	P-value
Frontal_Sup_Orb_L-Frontal_Sup_L	−0.226	0.008
Frontal_Sup_Orb_L-Frontal_Sup_R	−0.210	0.005
Frontal_Sup_Orb_R-Frontal_Sup_R	−0.259	0.005
Frontal_Mid_L-Frontal_Sup_Orb_L	−0.233	0.000
Frontal_Mid_R-Frontal_Sup_R	−0.268	0.001
Frontal_Mid_Orb_L-Frontal_Sup_L	−0.289	0.001
Frontal_Mid_Orb_L-Frontal_Sup_R	−0.290	0.000
Frontal_Mid_Orb_L-Frontal_Mid_L	−0.272	0.003
Frontal_Mid_Orb_L-Frontal_Mid_R	−0.233	0.003
Frontal_Mid_Orb_R-Frontal_Sup_R	−0.238	0.002
Frontal_Sup_Medial_L-Frontal_Mid_Orb_L	−0.284	0.005
Frontal_Sup_Medial_R-Frontal_Mid_R	−0.233	0.004
Frontal_Sup_Medial_R-Frontal_Mid_Orb_L	−0.282	0.004
Frontal_Sup_Medial_R-Frontal_Mid_Orb_R	−0.208	0.008
Rectus_L-Frontal_Mid_R	−0.202	0.008
Cingulum_Ant_L-Frontal_Mid_L	−0.173	0.008
Cingulum_Ant_L-Frontal_Mid_R	−0.144	0.006
Cingulum_Ant_L-Frontal_Mid_Orb_R	−0.172	0.005
Cingulum_Ant_R-Frontal_Mid_Orb_R	−0.196	0.000
Cingulum_Mid_L-Frontal_Mid_L	−0.210	0.004
Cingulum_Mid_R-Frontal_Sup_R	−0.174	0.009
Cingulum_Mid_R-Frontal_Mid_L	−0.187	0.006
Cingulum_Mid_R-Frontal_Mid_Orb_R	−0.149	0.002
Cingulum_Post_R-Frontal_Mid_Orb_L	−0.191	0.008
Caudate_R-Frontal_Mid_Orb_R	−0.175	0.008
Thalamus_L-Frontal_Mid_Orb_L	−0.179	0.006
Temporal_Inf_L-Frontal_Mid_Orb_L	−0.255	0.007

Figure 1 Twelve nodes. The connection strength of brain networks among these nodes significantly decreases more in the patient group than in the control group. The line thickness between nodes indicates the strength of the computed measure on the respective link, quantified with marked number.

Figure 2 Three-dimensioned views by BrainNet Viewer; respectively, sagittal, axial, and coronal views, showing the same nodes as in Figure 1.

Figure 3 Nineteen nodes. The connection strength of brain networks among these nodes significantly increases more in the patient group than in the control group. The line thickness between nodes indicates the strength of the computed measure on the respective link, quantified with marked number.

Figure 4 Three-dimensioned views by BrainNet Viewer; respectively, sagittal, axial, and coronal view, showing the same nodes as in Figure 3.