ABCA7 Gene Expression and Genetic Association Study in Schizophrenia

Figures & data

Table 1 Demographic Data and Clinical Characteristics of 50 Control Subjects and 50 Schizophrenia Patients

	Control (n = 50)	Sch (n = 50)	p-value
Sex, male (%)	25 (50.0)	24 (48.0)	0.841
Age (years)	61.8 ± 0.51	62.1 ± 0.50	0.975
Age of onset (years)		30.5 ± 13.0
Duration of illness (years)		31.6 ± 13.4
Medication (chlorpromazine equivalent dose)		543.6 ± 364.9
BPRS (total score)		31.1 ± 10.4
DIEPSS (total score)		4.57 ± 3.57

Notes: There were no significant differences in sex or age between 50 control subjects and 50 schizophrenia patients. Sex: χ2 test, Age: Mann–Whitney U-test. Data are the mean ± SD.

Abbreviations: BPRS, Brief Psychiatric Rating Scale, DIEPSS, Drug-Induced Extra-Pyramidal Symptoms Scale.

Table 2 Genotype Distributions and Allele Frequencies of the Rs3764650

	Genotypes, n (%)			P	Allele Frequencies, n (%)
	T/T	T/G	G/G		T	G	P
Schizophrenia	299 (38.3)	346 (44.3)	136 (17.4)	0.49	944 (60.4)	618 (39.6)	0.85
Controls	191 (36.2)	251 (47.6)	85 (16.2)		633 (60.1)	421 (39.9)

Figure 1 The ABCA7 mRNA expression levels of 50 schizophrenia patients and 50 control subjects.