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Neuropsychiatric Disease and Treatment Volume 8, 2012 - Issue
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Original Research

Six-month treatment with atypical antipsychotic drugs decreased frontal-lobe levels of glutamate plus glutamine in early-stage first-episode schizophrenia

Naoki Goto1 Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Reiji Yoshimura1 Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, JapanCorrespondence[email protected]
,
Shingo Kakeda2 Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Joji Nishimura2 Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Junji Moriya2 Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Kenji Hayashi1 Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Asuka Katsuki1 Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Hikaru Hori1 Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Wakako Umene-Nakano1 Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Atsuko Ikenouchi-Sugita1 Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Yukunori Korogi2 Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
&
Jun Nakamura1 Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
 show all
Pages 119-122 | Published online: 03 Apr 2012

Figures & data

Figure 1 The ratios of Glx/Cr in the three brain regions.

Note: *P < 0.05.
Abbreviations: Glx, glutamate plus glutamine; Cr, creatine; F, frontal lobe; LB, left basal ganglia; O, parieto-occipital lobe; HC, healthy control; SC, early-stage first-episode schizophrenia.
Figure 1 The ratios of Glx/Cr in the three brain regions.

Figure 2 The changes in Glx/Cr before and 6 months after treatment with atypical antipsychotic drugs.

Note: *P < 0.05.
Abbreviations: Glx, glutamate plus glutamine; Cr, creatine; F, frontal lobe; LB, left basal ganglia; O, parieto-occipital lobe; B, before treatment with atypical antipsychotic drugs; 6M, 6 months after treatment with atypical antipsychotic drugs.
Figure 2 The changes in Glx/Cr before and 6 months after treatment with atypical antipsychotic drugs.

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