The association of C3435T single-nucleotide polymorphism, Pgp-glycoprotein gene expression levels and carbamazepine maintenance dose in patients with epilepsy

Figures & data

Table 1 Characteristics of patients

	No	Sex	Age	Cryptogenic partial epilepsy	Symptomatic partial epilepsy	Generalized epilepsy	Other etiology
Epilepsy patients	162	76 (M) and 86 (F)	15–77	118	35	7	2
CBZ-resistant patients	68	35 (M) and 33 (F)	53 ± 14.5	53	11	3	1
CBZ-responder patients	94	41 (M) and 53 (F)		65	24	4	1

Abbreviation: CBZ, carbamazepine.

Table 2 Allele and genotype distribution in epilepsy patients from the Republic of Macedonia

	Allele		Adjuster OR 95% CI	P-value	Genotype			Adjuster OR 95% CI	P-value
	C	T			CC	CT	TT
CBZ-responsive patients	95 (0.51)	93 (0.49)	1.052 0.677–1.636	0.82187	25 (0.27)	45 (0.53)	24 (0.20)	1,116 0.445–2.797	0.81476
CBZ-resistant patients	69 (0.51)	67 (0.49)	0.951 0.611–1.478		15 (0.22)	39 (0.57)	14 (0.21)	0896 0.357–2.246

Abbreviations: CBZ, carbamazepine; CI, confidence interval; OR, odds ratio.

Figure 1 Distribution of CBZ dose in mg among different genotypes.

Abbreviation: CBZ, carbamazepine.

Table 3 Distribution of CBZ dose among CBZ-responsive patients with different genotypes from the Republic of Macedonia

	200	400	600	800	1000	1200	Total	Mann–Whitney test
								CC/CT	CT/TT	CC/TT	CC + CT/TT	CC/CT+TT
CC	4	13	2	3	0	2	24
CT	1	19	13	10	1	1	45	P = 0.0957	P = 0.8717	P = 0.1820	P = 0.7644	P = 0.4473
TT	2	11	2	6	1	3	25	U = 434	U = 549.5	U = 247.5	U = 263.5	U = 293.0
Total	7	43	17	19	2	6	94

Note: CC/CT/TT Kruskal–Wallis test: H = 0.91; P = 0.63.

Abbreviation: CBZ, carbamazepine.

Figure 2 Likelihood of a positive response to CBZ therapy between patients with different genotypes.

Abbreviation: CBZ, carbamazepine.

Figure 3 Likelihood of a positive response to CBZ therapy between patients with CC + CT genotypes vs TT genotype.

Abbreviation: CBZ, carbamazepine.

Figure 4 Likelihood of a positive response to carbamazepine therapy in patients with CC+CT genotypes vs TT genotypes.

Abbreviation: nt, nucleotides.

Figure 5 Distribution of total plasma concentration (TPC) among different genotypes.

Abbreviation: CBZ, carbamazepine.