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Original Research

Safety and tolerability of switching to asenapine from other antipsychotic agents: pooled results from two randomized multicenter trials in stable patients with persistent negative symptoms in schizophrenia

, , , &
Pages 247-257 | Published online: 15 Jun 2012

Figures & data

Figure 1 Trial design.

Abbreviations: bid, twice daily; qd, once daily.
Figure 1 Trial design.

Table 1 Patient demographic and baseline characteristics

Table 2 Summary of pretreatment antipsychotic drug use during cross-titration period

Figure 2 Kaplan–Meier curve of time to discontinuation of antipsychotics.

Figure 2 Kaplan–Meier curve of time to discontinuation of antipsychotics.

Figure 3 Subjects reporting adverse events (AEs) by antipsychotic agent type during the switch period.

Abbreviations: FGA, first-generation antipsychotic; SGA, second-generation antipsychotic.
Figure 3 Subjects reporting adverse events (AEs) by antipsychotic agent type during the switch period.

Table 3 Adverse events (AEs) in patients treated with second-generation antipsychotics during the switch period

Figure 4 Rate of (A) somnolence, (B) insomnia, and (C) incidence of weight gain by antipsychotic taken during the switch period.

Abbreviations: FGA, first-generation antipsychotic (most frequently used); SGA, second-generation antipsychotic.
Figure 4 Rate of (A) somnolence, (B) insomnia, and (C) incidence of weight gain by antipsychotic taken during the switch period.

Table 4 Adverse events (AEs) in patients treated with first-generation antipsychotics (including depot) during the switch period

Table 5 Adverse events (AEs) in patients treated with depot medications during the switch period

Table 6 Effect of number of pre-switch antipsychotics used during switch on incidence of adverse events over the full treatment period (26 weeks)