Twelve-month, prospective, open-label study of repetitive transcranial magnetic stimulation for major depressive disorder in partial remission

Figures & data

Table 1 Baseline characteristics and Thai HAM-D scores on follow-up visits for up to 12 months

Gender	Age	Years on treatment (n)	Antidepressant (mg/day)	Baseline	2 months	4 months	6 months	8 months	10 months	12 months
F	30	1	Fluoxetine (20) and nortriptyline (25)	17	4	5	9	6	9	5
F	53	1	Sertaline (50) and trazodone (50)	12	5	5	5	6	6	5
F	47	1	Escitalopram (10)	12	6	8	6	5	6	6
F	55	2	Fluoxetine (20)	13	8	7	6	5	6	6
F	57	13	Venlafaxine (75)	14	7	3	5	3	7	5
F	59	10	Fluoxetine (40)	12	7	6	7	7	5	8
F	58	10	Sertaline (50)	15	6	6	6	7	9	10
M	28	1	Mirtazapine (30)	10	9	7	7	6	8	7
M	27	10	Escitalopam (20)	11	5	5	5	6	4	6
Mean	46	5.44		12.89	6.33	5.78	6.22	5.67	6.67	6.45
SD	13.72	5.13		2.15	1.58	1.48	1.30	1.23	1.73	1.67

Abbreviations: SD, standard deviation; HAM-D, Hamilton Depression score.

Figure 1 Mean score of HAM-D subscales that were significantly decreased during the 12-month follow-up.

Abbreviation: HAM-D, Hamilton Depression score.

Figure 2 Mean score of HAM-D subscales that were not significantly changed during the 12-month follow-up.

Abbreviations: GI, Gastrointestinal; HAM-D, Hamilton Depression score.

Table 2 HAM-D subscale evaluated every 2 months for 12 months using Friedman test

HAM-D subscale	P value	Chi-square	df
Depressed mood	0.074	11.51	6
Feelings of guilt	0.254	7.79	6
Suicide	0.309	7.14	6
Early insomnia	0.038	13.35	6
Middle insomnia	0.014	15.89	6
Insomnia late	0.423	6.00	6
Work and activity	0.025	14.48	6
Psychomotor retardation	0.005	18.63	6
Agitation	0.062	12.00	6
Anxiety (psychosomatic)	0.010	16.71	6
Anxiety (somatic)	0.200	8.55	6
GI somatic symptoms	0.423	6.00	6
General somatic symptoms	0.018	15.13	6
Genital symptoms	0.421	6.02	6
Hypochondriasis	0.088	11.01	6
Loss of weight	NA†	NA†	NA†
Insight	0.062	12.00	6

Notes:

† Not available. No patient reported weight loss at any visit.

Abbreviations: df, degrees of freedom; GI, gastrointestinal; SD, standard deviation; HAM-D, Hamilton Depression score.