Effect of triiodothyronine (T₃) augmentation of acute milnacipran administration on monoamine levels: an in vivo microdialysis study in rats

Figures & data

Table 1 Effect of subchronic treatment with T₃ (for 7 days) on baseline concentrations of serotonin, norepinephrine, and dopamine in the medial prefrontal cortex and the amygdale

	Control n = 7	T3 0.1 mg/kg n = 6
Medial prefrontal cortex T3 0.1 mg/kg
Serotonin	0.793 ± 0.084	1.349 ± 0.234*
Norepinephrine	1.171 ± 0.107	1.060 ± 0.150
Dopamine	0.246 ± 0.027	0.220 ± 0.024
	Control n = 6	T3 0.2 mg/kg n = 6
Medial prefrontal cortex T3 0.2 mg/kg
Serotonin	1.08 ± 0.22	1.12 ± 0.37
Norepinephrine	0.880 ± 0.164	0.827 ± 0.171
Dopamine	0.242 ± 0.039	0.237 ± 0.037
	Control n = 3	T3 0.1 mg/kg n = 4
Amygdala T3 0.1 mg/kg
Serotonin	0.259 ± 0.024	0.342 ± 0.035
Norepinephrine	0.561 ± 0.072	0.760 ± 0.139
Dopamine	0.504 ± 0.039	0.606 ± 0.121

Notes: Values represent mean ± standard error of the mean (pg per 20-minute fraction); n = number of animals in each group; data are calculated from Figures 1–3;

* P < 0.05 compared with control group.

Figure 1 Effect of acute intraperitoneal administration of milnacipran 10 mg/kg on extracellular concentrations of serotonin (A), norepinephrine (B), and dopamine (C) in the medial prefrontal cortex after subchronic treatment with T₃ 0.1 mg/kg.

Notes: Values represent the mean ± standard error of the mean (pg per 20-minute fraction). Black arrows indicate milnacipran administration. [n = 7 (control group), n = 6 (T₃ 0.1 mg/kg group)]. *P < 0.05 versus control group.

Figure 2 Effect of acute intraperitoneal administration of milnacipran 10 mg/kg on extracellular concentrations of serotonin (A), norepinephrine (B), and dopamine (C) in the medial prefrontal cortex after subchronic treatment with T₃ 0.2 mg/kg.

Notes: Values represent the mean ± standard error of the mean (pg per 20-minute fraction). Black arrows indicate milnacipran administration. [n = 6 (control group), n = 6 (T₃ 0.2 mg/kg group)].

Figure 3 Effect of acute intraperitoneal administration of milnacipran 10 mg/kg on extracellular concentrations of serotonin (A), norepinephrine (B), and dopamine (C) in the amygdala after subchronic treatment with T₃ 0.1 mg/kg.

Notes: Values represent the mean ± standard error of the mean (pg per 20-minute fraction). Black arrows indicate milnacipran administration. [n = 3 (control group), n = 4 (T₃ 0.1 mg/kg group)].