CACNA1C Gene rs1006737 Polymorphism Affects Cognitive Performance in Chinese Han Schizophrenia

Figures & data

Table 1 Characteristics of SCZ Patients and Healthy Controls

Parameters	SCZ (n = 312)	Controls (n = 305)	P
Age (years)	40.26±12.70	40.60±13.32	0.743
Gender (female%)	48.08%	49.18%	0.697
Education (years)	11.43±3.23	11.75±3.44	0.232
Duration (years)	16.46±11.87	–	–
Age at onset (years)	25.06±5.62	–	–
Hospitalization times	3.00±1.23	–	–
PANSS	57.33±15.92	–	–
Mood stabilizers (%)	8.33%	–	–
Benzodiazepines (%)	12.50%	–	–
SGA (%)	96.47%	–	–

Abbreviations: SCZ, schizophrenia; PANSS, Positive and Negative Syndrome Scale; SGA, second generation antipsychotics.

Table 2 Genotype and Allele Distribution Frequency in rs1006737, rs1024582, rs2007044

SNP ID	Genotypes	Groups		X^2	P
		SCZ	Controls
rs1006737	AA+AG/GG	36/276	31/274	0.338	0.845
	A%	6.25	5.57	0.253	0.615
rs1024582	TT+TC/CC	30/282	26/279	0.742	0.690
	T%	4.97	4.59	0.097	0.756
rs2007044	GG+GA/AA	166/146	161/144	0.035	0.983
	G%	31.57	31.15	0.026	0.873

Abbreviations: SNP, single nucleotide polymorphism; SCZ, schizophrenia.

Table 3 Comparison of RBANS Scores Between Risk Allele Carriers and Non-Carriers in SCZ Group

SNP ID	Index Score	Carrirer	No-Carrier	F	P
rs1006737	Immediate Memory	66.64±16.79	69.29±18.24	2.395	0.409
	Visuospatical/Constructional	85.56±18.22	87.52±18.87	0.157	0.556
	Language	76.42±19.72	83.26±20.62	0.155	0.061
	Attention	78.33±21.01	80.10±20.38	0.233	0.626
	Delayed Memory	73.33±17.43	80.00±18.84	0.629	0.045*
	Total	70.81±15.49	75.26±16.63	0.290	0.129
rs1024582	Immediate Memory	67.77±16.99	69.11±18.21	1.443	0.699
	Visuospatical/Constructional	89.17±19.16	87.09±18.76	0.045	0.566
	Language	78.13±21.53	82.93±20.49	0.850	0.226
	Attention	84.37±22.87	79.42±20.14	0.664	0.208
	Delayed Memory	77.60±21.09	79.40±18.55	0.983	0.618
	Total	75.07±16.67	74.71±16.56	0.694	0.911
rs2007044	Immediate Memory	68.73±18.09	69.27±18.12	0.006	0.791
	Visuospatical/Constructional	88.10±18.63	86.37±18.97	0.261	0.417
	Language	83.30±20.17	81.52±21.11	1.141	0.446
	Attention	81.93±20.75	77.58±19.87	0.115	0.060
	Delayed Memory	79.63±17.84	78.77±19.84	2.187	0.685
	Total	75.43±16.19	73.96±16.95	0.485	0.433

Note: *P-value <0.05.

Abbreviations: RBANS, Repeatable Battery for the Assessment of Neuropsychological Status; SCZ, schizophrenia; SNP, single nucleotide polymorphism.

Figure 1 Comparison of RBANS scores between risk allele carriers and non-carriers in the SCZ group. *P-value <0.05. In rs1006737, the risk allele carriers had significantly lower scores than non-carriers, while in rs1024582 and rs2007044, there was no significant difference between the risk allele carriers and non-carriers.Abbreviations: RBANS, Repeatable Battery for the Assessment of Neuropsychological Status; SCZ, schizophrenia.

Figure 2 Heat map of correlation between characteristics and cognitive score in SCZ group. The RBANS total score of SCZ patients were negatively correlated with age, duration, and PANSS, but had no significant correlation with age of onset, education level, and hospitalization times.Abbreviations: SCZ, schizophrenia; PANSS, Positive and Negative Syndrome Scale; RBANS, Repeatable Battery for the Assessment of Neuropsychological Status.