Study on the Changes in Circadian Rhythm Before and After Treatment and the Influencing Factors in Patients with Depression

Figures & data

Table 1 Demographic Data and Clinical Evaluation of Patients with Depression of Different Time Types at Baseline: N (%)

	Late Type (23)	Intermediate Type (87)	Early Type (44)	F value or χ^2 value	P
Gender
Male(45)	6 (13.33%)	27 (60.00%)	12 (26.67%)	0.328	0.849
Female(109)	17 (15.69%)	60 (55.05%)	32 (29.36%)
Age	40.22±14.65	41.85±14.23	48.20±9.18*	4.273	0.016
BMI	22.19±2.54	21.31±2.97	22.10±3.09	1.487	0.229
First episode/relapse
First episode (87)	12 (52.17%)	46 (52.88%)	29 (65.91%)	2.226	0.329
Relapse (67)	11 (47.83%)	41 (61.19%)	15 (34.09%)
HAMD-17	21.61±8.16	23.02±5.66	22.07±3.92	0.774	0.463
HAMA	19.61±9.44	21.16±9.36	21.30±5.09	0.359	0.699
MEQ	37.96±2.87	50.02±4.51	64.91±3.85**	327.362	<0.001
PSQI	14.91±2.21	14.23±3.54	14.55±3.59	0.410	0.664
SHAPS	44.87±4.35	43.57±2.19	46.64±6.92*	4.576	0.012
MFI-20	81.82±8.41	75.47±12.50	85.34±10.13**	11.718	<0.001

Notes: *Means P<0.05; **P<0.01. The BMI was calculated as weight (kg)/height² (m²).

Table 2 MEq Score Trend of Three Groups of Subjects with Different Time Types

Item	Group	Number of Cases	Visit Point					F value and P value
			0Wk	2Wk	4Wk	8Wk	12Wk
MEQ	Late type	23	37.96±2.87	42.39±6.60	50.70±7.24	52.96±7.80	55.00±8.20	FT=13.888, P<0.001
	Intermediate type	87	50.02±4.51	52.11±6.24	52.99±8.09	53.55±9.15	53.6±10.05	FI=9.669, P<0.001
	Early type	44	64.91±3.85	60.43±6.49	60.93±8.96	60.89±9.55	60.86±9.42	FT*I=43.828, P<0.001
HAMD-17	Late type	23	21.61±8.16	13.57±10.30	7.35±7.91	4.83±4.93	2.52±2.75	FT=479.759, P<0.001
	Intermediate type	87	23.02±5.66	14.01±7.33	7.72±6.17	5.43±5.84	4.09±4.15	FI=0.619, P=0.706
	Early type	44	22.07±3.92	13.41±4.53	8.05±3.61	5.89±2.66	4.27±2.68	FT*I=0.352, P=0.407

Table 3 Data Differences Between Chronotypes Change Group and Non-Change Group

	Change Group (75)	Non-Change Group (79)	F value or χ^2 value	P value
Gender
Male	18 (40.00%)	27 (60.00%)	3.899	0.048
Female	57 (52.29%)	52 (47.71%)
Age	41.13±12.79	45.65±13.81	2.104	0.037
BMI	21.81±2.91	20.83±3.01	2.052	0.042
First episode/relapse
First episode	49 (55.68%)	39 (44.32%)	4.005	0.045
Relapse	26 (39.39%)	40 (60.61%)
Type of medication
Agomelatine	34 (45.33%)	23 (29.11%)	4.341	0.037
SSRI	41 (54.67%)	56 (70.89%)
Baseline-HAMD-17	22.43±6.67	22.65±4.57	0.238	0.812
Baseline-HAMA	21.19±9.54	20.76±7.09	0.316	0.752
Baseline-MEQ	49.47±9.68	54.77±8.52	3.616	<0.001
Baseline-PSQI	14.75±3.35	14.11±3.40	1.163	0.247
Baseline-SHAPS	43.00±5.20	40.56±5.27	2.890	0.004
Baseline-MFI-20	77.89±12.15	80.50±12.04	1.333	0.185

Note: The BMI was calculated as weight (kg)/height² (m²).

Table 4 Logistic Regression Model of Influencing Factors in Depressive Patients’ Circadian Rhythm Returning to Early Type

	β value	Standard Error	Wald	OR value	P value	95% Confidence Interval
						Lower Limit	Upper Limit
(constant)	−1.607	1.868	0.741	0.200	0.389
Type of medication	0.714	0.434	2.706	0.689	0.047	1.209	1.947
Baseline MEQ	−0.084	0.026	10.516	0.919	0.001	0.874	0.967
Baseline SHAPS	0.107	0.033	10.616	1.113	0.001	1.043	1.186