Update on once-daily zonisamide monotherapy in partial seizures

Figures & data

Table 1 Open-label prospective studies of zonisamide monotherapy

Reference	Type of epilepsy	Patients, n (characteristics)	Zonisamide dosage	% LR seizure-free
Fujii et al^Citation17	LR	25 (treatment-naïve)	8 mg/kg/day	68%
Kumagai et al^Citation18	LR and generalized	44 (pediatric)	12 mg/kg/day	72%
Hayakawa et al^Citation19	LR and generalized	32 (pediatric, newly diagnosed)	2–10 mg/kg/day	66%
Yagi and Seki^Citation20	LR and generalized	65 (pediatric, refractory)	6 mg/kg/day	*
Miura^Citation21	LR	72 (pediatric, treatment-naïve)	8 mg/kg/day	79.2%
Seki et al^Citation22	LR and generalized	68 (pediatric)	up to 12 mg/kg/day	82%

Note:

* Only >50% reduction in seizure frequency was reported (see text under efficacy of zonisamide as monotherapy).

Abbreviation: LR, localization related.

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