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ORIGINAL RESEARCH

The Role of ElastPQ in Assessing Liver Stiffness for Non-Alcoholic Fatty Liver Disease in Patients Treated with Atypical Antipsychotic Drugs

ORCID Icon, , & ORCID Icon
Pages 1491-1502 | Received 03 Mar 2023, Accepted 14 Jun 2023, Published online: 30 Jun 2023

Figures & data

Figure 1 Subject flow chart of the present study.

Figure 1 Subject flow chart of the present study.

Figure 2 Schematic diagram of sonographic features for fatty liver diagnosis.

Figure 2 Schematic diagram of sonographic features for fatty liver diagnosis.

Table 1 Characteristics of the Study Population

Table 2 The Stiffness Value Using ElsatPQ in Different Stages of Fatty Liver

Figure 3 Box plot of the ElastPQ values in different fatty liver degrees. In the normal liver, the stiffness value obtained by ElastPQ was 3.48(3.14–3.81) kPa, whereas it was 3.39(3.07–3.67) kPa in the patients and 3.25(3.31–4.01) kPa in the control, respectively. For mild fatty liver, the stiffness value was 4.45(4.14–4.81) kPa, 4.35(4.21–4.62) kPa in the patients, and 4.33(3.82–4.58) kPa in the control, respectively. For moderate fatty liver, the stiffness value was 5.82(5.13–6.11) kPa, while 5.53(5.82–6.78) kPa in the patients and 5.37(4.91–5.78) kPa in the control, respectively. The liver stiffness value was 8.15(6.44–9.88) in the severe fatty liver, whereas 8.50(7.08–10.93) kPa in the patients and 6.6(6.1–8.1) kPa in the control, respectively. The blue bar represents the values in the patients, and the red bar represents the values in the control.

Figure 3 Box plot of the ElastPQ values in different fatty liver degrees. In the normal liver, the stiffness value obtained by ElastPQ was 3.48(3.14–3.81) kPa, whereas it was 3.39(3.07–3.67) kPa in the patients and 3.25(3.31–4.01) kPa in the control, respectively. For mild fatty liver, the stiffness value was 4.45(4.14–4.81) kPa, 4.35(4.21–4.62) kPa in the patients, and 4.33(3.82–4.58) kPa in the control, respectively. For moderate fatty liver, the stiffness value was 5.82(5.13–6.11) kPa, while 5.53(5.82–6.78) kPa in the patients and 5.37(4.91–5.78) kPa in the control, respectively. The liver stiffness value was 8.15(6.44–9.88) in the severe fatty liver, whereas 8.50(7.08–10.93) kPa in the patients and 6.6(6.1–8.1) kPa in the control, respectively. The blue bar represents the values in the patients, and the red bar represents the values in the control.

Table 3 The AUC, Cut-off Value, Sensitivity, and Specificity for the Diagnosis of Fatty Liver Grade

Figure 4 The receiver operating characteristic curves for ElastPQ values used for the detection and differentiation of fatty liver grades.

Figure 4 The receiver operating characteristic curves for ElastPQ values used for the detection and differentiation of fatty liver grades.

Table 4 The Result of ElastPQ and Fatty Liver in Different Types of AAPs

Table 5 The Variation of ElastPQ in Different Treatment Time