Analysis of individual items on the attention-deficit/hyperactivity disorder symptom rating scale in children and adults: the effects of age and sex in pivotal trials of lisdexamfetamine dimesylate

Figures & data

Figure 1 ADHD-RS-IV mean item scores overall at baseline and endpoint, in (A) the child study and (B) the adult study.

Notes: © 1998 Guildford Press. Adapted with permission from DuPaul GJ, Power TJ, Anastopoulos AD, Reid R. ADHD Rating Scale-IV: Checklists, Norms, and Clinical Interpretation. New York, NY: Guilford Press; 1998.³⁸ Odd numbers = inattention items; even numbers = hyperactivity/impulsivity items. Adult prompts were used in the adult study. Bold text represents a hyperactivity/impulsivity item.
Abbreviations: ADHD-RS-IV, Attention-Deficit/Hyperactivity Disorder Rating Scale IV; LDX, lisdexamfetamine dimesylate; SD, standard deviation.

Figure 2 ADHD-RS-IV mean item scores by pediatric age and sex subgroups at baseline and endpoint. (A) Shows boys and girls aged 6 to 9 years; (B) shows boys and girls aged 10 to 12 years.

Notes: © 1998 Guildford Press. Adapted with permission from DuPaul GJ, Power TJ, Anastopoulos AD, Reid R. ADHD Rating Scale-IV: Checklists, Norms, and Clinical Interpretation. New York, NY: Guilford Press; 1998.³⁸ Odd numbers = inattention items; even numbers = hyperactivity/impulsivity items. Adult prompts were used in the adult study. Bold text represents a hyperactivity/impulsivity item.
Abbreviations: ADHD-RS-IV, Attention-Deficit/Hyperactivity Disorder Rating Scale IV; LDX, lisdexamfetamine dimesylate; SD, standard deviation.

Figure 3 ADHD-RS-IV mean item scores by adult age and sex subgroups at baseline and endpoint. (A) Shows men and women aged 18 to 39 years; (B) shows men and women aged 40 to 55 years.

Notes: © 1998 Guildford Press. Adapted with permission from DuPaul GJ, Power TJ, Anastopoulos AD, Reid R. ADHD Rating Scale-IV: Checklists, Norms, and Clinical Interpretation. New York, NY: Guilford Press; 1998.³⁸ Odd numbers = inattention items; even numbers = hyperactivity/impulsivity items. Adult prompts were used in the adult study. Bold text represents a hyperactivity/impulsivity item.
Abbreviations: ADHD-RS-IV, Attention-Deficit/Hyperactivity Disorder Rating Scale IV; LDX, lisdexamfetamine dimesylate; SD, standard deviation.

Table 1 Participant disposition and baseline demographic data

Disposition	Pediatric clinical trial	Adult clinical trial
Treated population
n	285	414
Placebo, n (%)	72 (25.3)	62 (15.0)
Active, n (%)	213 (74.7)	352 (85.0)
Disposition, n (%)
Completed	230 (80.7)	349 (84.3)
Discontinued	55 (19.3)	65 (15.7)
Treatment-emergent adverse events	21 (7.4)	21 (5.1)
Lack of efficacy	14 (4.9)	8 (1.9)
Protocol violation	3 (1.1)	16 (3.9)
Lost to follow-up	9 (3.2)	5 (1.2)
Withdrew consent	3 (1.1)	9 (2.2)
Physician decision	1 (0.4)	2 (0.5)
Other	4 (1.4)	4 (1.0)
Baseline demographic data
Age, mean (SD), y	9.0 (1.8)	35.2 (10.3)
Sex, n (%)
Female	88 (30.9)	190 (45.9)
Male	197 (69.1)	224 (54.1)
Age groups by sex, n (%)
Female aged 6–9 years	53 (18.6)
Female aged 10–12 years	35 (12.3)
Male aged 6–9 years	119 (41.8)
Male aged 10–12 years	78 (27.4)
Female aged 18–39 years		109 (26.3)
Female aged 40–55 years		81 (19.6)
Male aged 18–39 years		153 (37.0)
Male 40–55 aged years		71 (17.1)
Race/ethnicity, n (%)
African  American	69 (24.2)	14 (3.4)
Asian	3 (1.1)	4 (1.0)
Caucasian	152 (53.3)	344 (83.1)
Hispanic	48 (16.8)	39 (9.4)
Native American	2 (0.7)	3 (0.7)
Other	11 (3.9)	10 (2.4)
Global severity (CGI-S), n (%)
Mildly ill	1 (0.4)	0
Moderately ill	101 (35.4)	139 (33.6)
Markedly ill	134 (47.0)	218 (52.7)
Severely ill	45 (15.8)	56 (13.5)
Extremely ill	4 (1.4)	1 (0.2)

Abbreviations: CGI-S, Clinical Global Impressions-Severity scale; n, number; SD, standard deviation; y, year.

DuPaulGJPowerTJAnastopoulosADReidRADHD Rating Scale-IV: Checklists, Norms, and Clinical InterpretationNew York, NYGuilford Press1998

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