Figures & data
Notes: Molecular weight is 529.13698 g/mol and molecular formula is C28H37ClN4O2S. Teal atoms represent hydrogen, gray atoms carbon, red atoms oxygen, blue atoms nitrogen, and the yellow atom a sulfur; the associated hydrogen chloride salt is not pictured.Citation18
Notes: (A) Mean change in MADRS from baseline to week 6 across different treatments in patients with bipolar I depression. (B) The mean change in depression severity score on the CGI scale from baseline to week 6 for the same treatment groups. Placebo, 20–60 mg/day and 80–120 mg/day values reported in Loebel’s monotherapy study;Citation39 adjunct experimental values from Loebel et al’s investigation of lurasidone as adjunctive treatment with lithium and valproate.Citation40
Abbreviations: MADRS, Montgomery–Åsberg Depression Rating Scale; CGI-BP, Clinical Global Impressions Scale for use in bipolar illness; d, day.
Abbreviations: MADRS, Montgomery–Åsberg Depression Rating Scale; CGI-BP, Clinical Global Impressions Scale for use in bipolar illness; d, day.