Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study

Figures & data

Table 1 Qualitative and quantitative composition of Illumina®

Components	Content per tablet
Microalgae (Haematococcus pluvialis) dry extract 3%	74 mg
Astaxanthin	2 mg
Bacopa monnieri dry extract 20%	100 mg
Bacosides	20 mg
Phosphatidylserine (extracted from soy)	30 mg
Vitamin E (vegetable origin)	30 mg

Note: Illumina® (Cristalfarma, Milan, Italy).

Table 2 ADAS-cog and clock drawing test scores before and after treatment with Illumina®

Test administered	Time	N	Mean	Standard deviation	t-test	P-value
ADAS-cog	D0	102	13.65	5.78	11.177	<0.001
	D60	102	9.65	4.89
Clock drawing test	D0	102	8.46	2.29	−4.521	<0.001
	D60	102	9.07	1.92

Note: Illumina® (Cristalfarma, Milan, Italy).Abbreviations: ADAS-cog, Alzheimer’s Disease Assessment Scale-cognitive subscale; D0, day 0; D60, day 60.

Figure 1 Mean ± standard deviation scores of individual ADAS-cog components before and after treatment with Illumina®.

Note: Illumina® (Cristalfarma, Milan, Italy).
Abbreviations: ADAS-cog, Alzheimer’s Disease Assessment Scale-cognitive subscale; D0, day 0; D60, day 60.