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Original Research

Agomelatine in the treatment of depressive disorders in clinical practice: multicenter observational CHRONOS study

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Pages 631-639 | Published online: 17 Apr 2014

Figures & data

Table 1 Demographic and clinical characteristics of patients at baseline

Figure 1 Mean 17-item Hamilton Rating Scale for Depression (HAMD-17) total score during the 8-week treatment period.

Note: *P<0.0001.
Figure 1 Mean 17-item Hamilton Rating Scale for Depression (HAMD-17) total score during the 8-week treatment period.

Figure 2 Proportions of patients showing response to treatment (responders: HAMD-17 total score decreased by ≥50% from baseline) and remission (remitters: HAMD-17 total score <7 during the treatment period, indicating they were free from depression) during the 8-week treatment period.

Abbreviation: HAMD-17, 17-item Hamilton Rating Scale for Depression.
Figure 2 Proportions of patients showing response to treatment (responders: HAMD-17 total score decreased by ≥50% from baseline) and remission (remitters: HAMD-17 total score <7 during the treatment period, indicating they were free from depression) during the 8-week treatment period.

Figure 3 Mean single Hamilton Rating Scale for Depression item scores for “work and activities” (item 7) and “psychomotor retardation” (item 8) during the 8-week treatment period.

Note: *P<0.0001.
Abbreviation: HAMD-17, 17-item Hamilton Rating Scale for Depression.
Figure 3 Mean single Hamilton Rating Scale for Depression item scores for “work and activities” (item 7) and “psychomotor retardation” (item 8) during the 8-week treatment period.

Figure 4 Upper panel: frequency distribution of Clinical Global Impression Severity Scale (CGI-S) scores after 8 weeks of treatment.

Notes: Lower panel: proportion of patients either markedly or severely ill (CGI-S score 5 or 6) throughout the treatment period.
Figure 4 Upper panel: frequency distribution of Clinical Global Impression Severity Scale (CGI-S) scores after 8 weeks of treatment.

Figure 5 Subgroup of more severely ill patients. Proportions of patients showing response to treatment (responders: HAMD-17 total score decreased by ≥50% from baseline) and remission (remitters: HAMD-17 total score <7 during the treatment period, indicating they were free from depression) in the subgroup of patients (n=3,478) with HAMD-17 total score ≥21 at baseline.

Abbreviation: HAMD-17, 17-item Hamilton Rating Scale for Depression.
Figure 5 Subgroup of more severely ill patients. Proportions of patients showing response to treatment (responders: HAMD-17 total score decreased by ≥50% from baseline) and remission (remitters: HAMD-17 total score <7 during the treatment period, indicating they were free from depression) in the subgroup of patients (n=3,478) with HAMD-17 total score ≥21 at baseline.

Table 2 Adverse events reported by ≥0.25% of patients