Influence of valproate on the required dose of propofol for anesthesia during electroconvulsive therapy of bipolar affective disorder patients

Figures & data

Table 1 Sociodemographic characteristics

Characteristic	Valproate group	Valproate-free group
Age, years ± SD	32.6±6.5	33.1 ±5.6
Disease duration, years ± SD	3.8±1.5	3.9±1.7
Sex, n (%)
Male	9 (52.9)	9 (56.3)
Female	8 (47.1)	7 (43.8)
BMI (kg/m^2) (mean ± SD)	22.9±3.13	22.18±3.12

Abbreviations: BMI, body mass index; SD, standard deviation.

Table 2 Propofol dose, valproate plasma levels, and seizure durations of patients

Parameter	Patients	1st session	2nd session	3rd session	4th session	5th session
Propofol dosage (mg/kg)	Valproate using	1.06	1.15	1.08	1.05	1.06
	Valproate free	1.50	1.55	1.50	1.60	1.63
	P	0.03	0.01	0.03	0.01	0.01
Seizure duration (seconds)	Valproate using	29.7	27.4	24.1	30.2	26.0
	Valproate free	44.5	35.2	54.0	43.5	51.7
	P	0.031	0.069	0.002	0.021	0.002
Therapeutic range: 50–100 mcg/mL		22.4	26.5	22.4	20.0	24.5