Factors associated with early response to olanzapine and clinical and functional outcomes of early responders treated for schizophrenia in the People’s Republic of China

Figures & data

Table 1 Baseline characteristics

Variable	Early nonresponders (n=194)	Early responders (n=130)	P-value
Age, mean (SD), years	30.2 (11.1)	27.8 (9.1)	0.036
Female, n (%)	100 (51.5)	74 (56.9)	0.365
Education, n (%)			0.727
<High school	48 (24.9)	27 (20.8)
High school	66 (34.2)	52 (40.0)
University	79 (40.9)	51 (39.2)
Marital status, n (%)			0.360
Married	62 (32.0)	38 (29.2)
Domestic partner	105 (54.1)	66 (50.8)
No relationship	27 (13.9)	26 (20.0)
Working for pay, n (%)	24 (12.4)	18 (13.8)	0.737
Any dependents, n (%)	89 (46.4)	65 (50.0)	0.570
Duration of illness, mean (SD), years	5.3 (8.7)	2.4 (4.7)	<0.001
Paranoid subtype, n (%)	115 (59.6)	84 (65.1)	0.350
Antipsychotics or mood stabilizers,a n (%)	128 (66.0)	95 (73.1)	0.181
Other psychiatric medications,a n (%)	74 (38.1)	38 (29.2)	0.121
History of antipsychotic treatment,b n (%)	119 (62.6)	72 (56.7)	0.295
Ever smoked, n (%)	44 (23.5)	24 (20.0)	0.485
CGI-S, mean (SD)	4.6 (1.1)	5.0 (1.0)	0.006
Social activities, mean (SD)	1.5 (1.7)	2.0 (1.9)	0.037
Insight, mean (SD)	1.4 (1.3)	1.3 (1.1)	0.444
Impairment in work, mean (SD)	2.5 (1.2)	2.3 (1.2)	0.280
Life satisfaction, n (%)			0.089
Dissatisfied	85 (43.8)	71 (54.6)
Neither	69 (35.6)	32 (24.6)
Satisfied	40 (20.6)	27 (20.8)
BMI, mean (SD), kg/m^2	22.2 (2.8)	21.6 (3.2)	0.108
Weight control program, n (%)	49 (25.3)	43 (33.1)	0.133
Low physical activity, n (%)	21 (10.8)	7 (5.4)	0.107
Prior AP weight gain, n (%)	19 (9.8)	10 (7.7)	0.558

Notes:

a At baseline or during the 6 months prior to baseline;

b at any time in the patient’s history.

Abbreviations: AP, antipsychotic; BMI, body mass index; CGI-S, Clinical Global Impressions-Severity; SD, standard deviation.

Figure 1 Odds ratios from logistic regression model.

Note: Duration of illness, number of social activities, and CGI-S are numeric variables so the odds ratios represent the change in odds for every unit increase in the variable.
Abbreviation: CGI-S, Clinical Global Impressions-Severity.

Figure 2 CGI-S change from baseline across the 6-month study for early responders versus early nonresponders.

Notes: The overall P-value for the early responder effect in the mixed models for repeated measures was <0.001. ***P<0.001.
Abbreviation: CGI-S, Clinical Global Impressions-Severity.

Figure 3 Change from baseline in functional outcomes across the 6-month study for early responders versus early nonresponders.

Notes: The overall P-values for the early responder effect in the mixed models for repeated measures were <0.001, <0.001, 0.051, and 0.002 for patient insight into illness, work impairment, social activities, and life satisfaction changes, respectively. *P<0.05; **P<0.01; ***P<0.001.