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Original Research

Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia

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Pages 703-709 | Published online: 05 May 2014

Figures & data

Figure 1 (AC) The effects of thrombin (0.4 U/mL) and platelet-activating factor (PAF; 1×10−8 M) on the level of superoxide radicals in blood platelets isolated from healthy subjects and from schizophrenic schizophrenic patients (n=30). (A) Levels of superoxide radicals in resting platelets. (B) Levels of superoxide radicals in platelets after stimulation by thrombin (0.4 U/mL). (C) Levels of superoxide radicals in platelets after stimulation by PAF. Differences in anion radical generation in resting platelets and after agonist stimulation (thrombin or PAF) between groups calculated by Mann–Whitney U test.

Abbreviations: SD, standard deviation; SEM, standard error of mean.
Figure 1 (A–C) The effects of thrombin (0.4 U/mL) and platelet-activating factor (PAF; 1×10−8 M) on the level of superoxide radicals in blood platelets isolated from healthy subjects and from schizophrenic schizophrenic patients (n=30). (A) Levels of superoxide radicals in resting platelets. (B) Levels of superoxide radicals in platelets after stimulation by thrombin (0.4 U/mL). (C) Levels of superoxide radicals in platelets after stimulation by PAF. Differences in anion radical generation in resting platelets and after agonist stimulation (thrombin or PAF) between groups calculated by Mann–Whitney U test.

Figure 2 The activity of glutathione peroxidase (GPx) in platelets from patients with schizophrenia (n=30) and healthy subjects (control, n=30). Control group mean 182.5, standard error of mean 0.4 (minimum 178.9, maximum 186.8).

Figure 2 The activity of glutathione peroxidase (GPx) in platelets from patients with schizophrenia (n=30) and healthy subjects (control, n=30). Control group mean 182.5, standard error of mean 0.4 (minimum 178.9, maximum 186.8).