Genetic association between the dopamine D₁-receptor gene and paranoid schizophrenia in a northern Han Chinese population

Jun YaoInstitute of Forensic Medicine, China Medical University, Shenyang, People’s Republic of China

Mei DingInstitute of Forensic Medicine, China Medical University, Shenyang, People’s Republic of China

Jiaxin XingInstitute of Forensic Medicine, China Medical University, Shenyang, People’s Republic of China

Jinfeng XuanInstitute of Forensic Medicine, China Medical University, Shenyang, People’s Republic of China

Hao PangInstitute of Forensic Medicine, China Medical University, Shenyang, People’s Republic of China

Yuqing PanInstitute of Forensic Medicine, China Medical University, Shenyang, People’s Republic of China

Baojie WangInstitute of Forensic Medicine, China Medical University, Shenyang, People’s Republic of ChinaCorrespondence[email protected]

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Figures & data

Figure 1 Schematic diagram of the distribution of eleven SNP loci in the DRD1 gene.

Abbreviations: CDS, coding sequence; SNP, single nucleotide polymorphism; ATG, transcription start site; STOP, stop codon.

Figure 2 Linkage-disequilibrium diagram of eleven single-nucleotide polymorphism loci in DRD1. The top row represents the disease group, while the bottom shows the control group; the left is r², and the right is D′. The black grid represents r²=1; the blank grid represents D′=1.

Table 1 Distribution of genotype frequencies, allele frequencies, and disease risk at the eleven SNP loci in DRD1 for the control and disease groups

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Table 2 Haplotypes formed by the seven SNP loci in DRD1 and disease risk

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Table 3 Haplotypes formed by the remaining four SNP loci in DRD1 and disease risk

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Table 4 Distribution of genotype frequency and disease risk at two SNP loci in DRD1 for sex in control and disease groups

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Genetic association between the dopamine D₁-receptor gene and paranoid schizophrenia in a northern Han Chinese population

Table 1 Distribution of genotype frequencies, allele frequencies, and disease risk at the eleven SNP loci in DRD1 for the control and disease groups

Table 2 Haplotypes formed by the seven SNP loci in DRD1 and disease risk

Table 3 Haplotypes formed by the remaining four SNP loci in DRD1 and disease risk

Table 4 Distribution of genotype frequency and disease risk at two SNP loci in DRD1 for sex in control and disease groups

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Genetic association between the dopamine D1-receptor gene and paranoid schizophrenia in a northern Han Chinese population

Figures & data

Table 1 Distribution of genotype frequencies, allele frequencies, and disease risk at the eleven SNP loci in DRD1 for the control and disease groups

Table 2 Haplotypes formed by the seven SNP loci in DRD1 and disease risk

Table 3 Haplotypes formed by the remaining four SNP loci in DRD1 and disease risk

Table 4 Distribution of genotype frequency and disease risk at two SNP loci in DRD1 for sex in control and disease groups

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Genetic association between the dopamine D₁-receptor gene and paranoid schizophrenia in a northern Han Chinese population