Long-term functional improvements in the 2-year treatment of schizophrenia outpatients with olanzapine long-acting injection

Figures & data

Table 1 Baseline sociodemographic and clinical characteristics, by treatment

Characteristic	Olanzapine-LAI	Olanzapine	Pa
Number of patients	(n=264)	(n=260)
Female, n (%)	89 (33.7)	83 (31.9)	0.66
Age at study entry (years), mean (SD)	41.7 (10.9)	40.1 (10.8)	0.09
Age at onset (years), mean (SD)	25.9 (9.2)	26.5 (8.7)	0.28
CGI-S score, mean (SD)	3.2 (0.8)	3.3 (0.7)	0.82
PANSS total score, mean (SD)	56.7 (9.8)	56.6 (8.7)	0.43
In paid employment, n (%)	56 (21.3)	48 (18.5)	0.43
Living independently, n (%)	67 (25.5)	56 (21.6)	0.29

Note:

a P-value comparing olanzapine-LAI with oral olanzapine.

Abbreviations: LAI, long-acting injection; SD, standard deviation; CGI-S, Clinical Global Impression–Severity; PANSS, Positive and Negative Symptom Scale.

Table 2 Change in level of functioning per QLS total and QLS subscale scores from baseline to last observation, by treatment group

QLS score/visit	Olanzapine-LAIa	Pb	Oral olanzapine	Pb
QLS total score, mean (SD)
Baseline	64.0 (21.2)	<0.001	62.1 (18.8)	<0.001
Last observation years	70.8 (22.9)		70.1 (22.4)
QLS common objects and activities, mean (SD)
Baseline	6.6 (2.6)	<0.001	6.5 (2.5)	<0.001
Last observation	7.3 (2.6)		7.1 (2.6)
QLS intrapsychic foundation, mean (SD)
Baseline	21.9 (7.9)	<0.001	21.6 (6.9)	<0.001
Last observation	24.1 (8.7)		23.9 (8.4)
QLS intrapersonal relation, mean (SD)
Baseline	21.0 (10.0)	<0.001	20.0 (9.3)	<0.001
Last observation	24.2 (10.2)		23.9 (10.0)
QLS instrumental role, mean (SD)
Baseline	14.1 (3.6)	<0.001	13.9 (3.2)	<0.001
2 years	14.8 (3.9)		14.8 (3.8)

Note:

a There were no statistical differences between olanzapine-LAI and oral olanzapine in any of the ratings.

b P value; change from baseline to endpoint.

Abbreviations: LAI, long-acting injection; SD, standard deviation; QLS, Quality of Life Scale.

Table 3 Proportion of patients with “good”, “moderate”, and “poor” levels of functioning at baseline and last observation, by treatment group

Visit/functioning cluster	Olanzapine-LAI	Oral olanzapine	Total	Pa
Baseline, n (%)				0.11
“Good”	50 (19.2)	37 (14.2)	87
“Moderate”	150 (57.5)	172 (66.2)	322
“Poor”	61 (23.4)	51 (19.6)	112
2 years, n (%)				0.26
“Good”	66 (27.5)	56 (24.5)	122
“Moderate”	125 (52.1)	136 (59.4)	261
“Poor”	49 (20.4)	37 (16.2)	86

Note:

a P value comparing the proportion of patients in each cluster between olanzapine-LAI and oral olanzapine.

Abbreviation: LAI, long-acting injection.

Table 4 Baseline characteristics of the patients in the “good”, “moderate”, and “poor” functional clusters (all patients, n=524)

Characteristic	Functioning cluster			Pa
	“Good”	“Moderate”	“Poor”
Number of patients	(n=87)	(n=322)	(n=112)
Female, n (%)	33 (38)	102 (32)	36 (32)	0.5367
Age at study entry (years), mean (SD)	39.2 (11.4)	40.8 (10.7)	42.7 (10.9)	0.0928
Time since onset (years), mean (SD)	13.9 (11.2)	14.6 (10.2)	15.8 (10.7)	0.2367
CGI-S score, mean (SD)	2.7 (0.9)	3.3 (0.7)	3.5 (0.6)	<0.0001
PANSS total score, mean (SD)	50.0 (10.5)	57.1 (8.4)	60.3 (7.9)	<0.0001
In paid employment, n (%)	39 (45)	59 (18)	6 (5)	<0.0001
Living independently, n (%)	25 (29)	84 (26)	13 (12)	0.0032

Note:

a P value comparing the three clusters.

Abbreviations: SD, standard deviation; CGI-S, Clinical Global Impression-Severity; PANSS, Positive and Negative Symptom Scale.

Table 5 Proportion of patients in the “good”, “moderate”, and “poor” functioning clusters at last observation, by baseline functional cluster and treatment group

Treatment/functioning cluster at baseline	Functioning cluster at endpoint			Total, n
	“Good”	“Moderate”	“Poor”
Olanzapine-LAI, n (%)
“Good”	35 (76.1)	11 (23.9)	0 (0.0)	46
“Moderate”	26 (18.8)	93 (67.4)	19 (13.8)	138
“Poor”	5 (9.1)	20 (36.4)	30 (54.5)	55
Total, n (%)	66 (27.6)	124 (51.9)	49 (20.5)	239
Oral olanzapine, n (%)
“Good”	25 (73.5)	8 (23.5)	1 (2.9)	34
“Moderate”	30 (19.6)	110 (71.9)	13 (8.5)	153
“Poor”	1 (2.4)	18 (42.9)	23 (54.8)	42
Total, n (%)	56 (24.5)	136 (59.4)	37 (16.2)	229

Note:

There were no statistical differences between the change from baseline to endpoint for each of the functioning clusters when comparing olanzapine-LAI and oral olanzapine. Percentages may not =100, due to rounding.

Abbreviation: LAI, long-acting injection.