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Original Research

No change in N-acetyl aspartate in first episode of moderate depression after antidepressant treatment: 1H magnetic spectroscopy study of left amygdala and left dorsolateral prefrontal cortex

, , , , , , & show all
Pages 1753-1762 | Published online: 17 Sep 2014

Figures & data

Figure 1 Left dorsolateral prefrontal cortex.

Abbreviations: NAA, N-acetyl aspartate; Cr, creatine.
Figure 1 Left dorsolateral prefrontal cortex.

Figure 2 Left amygdala.

Abbreviations: NAA, N-acetyl aspartate; Cr, creatine.
Figure 2 Left amygdala.

Table 1 Group characteristics

Figure 3 Box plots of NAA/Cr, showing baseline and endpoint in DLPFC and amygdala for all subjects. Shown are medians (squares), interquartile ranges (boxes), and nonoutlier range (whiskers).

Abbreviations: NAA/Cr, N-acetyl aspartate/creatine ratio; DLPFC, dorsolateral prefrontal cortex; F1, baseline in DLPFC; F2, endpoint in DLPFC; A1, baseline in amygdala; A2, endpoint in amygdala.
Figure 3 Box plots of NAA/Cr, showing baseline and endpoint in DLPFC and amygdala for all subjects. Shown are medians (squares), interquartile ranges (boxes), and nonoutlier range (whiskers).

Figure 4 Box plots of NAA/Cr in responders and nonresponders to antidepressant treatment showing baseline and endpoint in DLPFC and amygdala. Shown are medians (squares), interquartile ranges (boxes), and nonoutlier range (whiskers).

Abbreviations: NAA/Cr, N-acetyl aspartate/creatine ratio; DLPFC, dorsolateral prefrontal cortex; F1, baseline in DLPFC; F2, endpoint in DLPFC; A1, baseline in amygdala; A2, endpoint in amygdala.
Figure 4 Box plots of NAA/Cr in responders and nonresponders to antidepressant treatment showing baseline and endpoint in DLPFC and amygdala. Shown are medians (squares), interquartile ranges (boxes), and nonoutlier range (whiskers).

Table 2 Changes in scales and NAA/Cr ratios from baseline to endpoint

Table 3 Correlations of changes in scale scores with changes in NAA/Cr ratios from baseline to endpoint

Table 4 Correlations of changes in scale scores with changes in NAA/Cr ratios from baseline to endpoint in responders and nonresponders