Examining the relationship between adherence and satisfaction with antidepressant treatment

Figures & data

Table 1 Characteristics of study participants and their level of treatment satisfaction

Factor	N (%)	Treatment satisfaction (mean)	SD
Sex
Male	200 (49.6)	79.21	8.52
Female**	203 (50.4)	86.55	14.34
Age
18–30 years	102 (25.1)	78.98	11.93
31–40 years	120 (29.9)	82.65	13.10
41–50 years	102 (25.1)	85.08	13.84
51–60 years*	80 (19.8)	86.68	8.93
Education level
No formal education	90 (22.5)	84.92	13.98
Primary	58 (14.4)	82.61	8.42
Intermediate	80 (19.8)	82.41	13.42
Secondary	130 (32.1)	83.58	11.82
College/bachelor degree	45 (11.2)	80.24	14.48
Number of antidepressant drugs currently taken
One	331 (82.3)	83.20	12.64
Two	72 (17.7)	82.84	12.08
Number of clinic visit per year
Once a year	28 (7.0)	67.53	8.47
Twice a year	41 (10.2)	78.55	9.41
Three times a year*	149 (36.9)	88.46	13.66
Four times a year*	185 (46.0)	82.23	9.94
Illness duration
≤3 years	114 (28.3)	81.38	12.01
>3 years to 6 years	92 (23.0)	82.63	14.31
>6 years to 9 years	172 (42.8)	83.96	12.17
>9 years	23 (5.9)	87.57	9.44

Notes: Student’s t-test for the difference in the characteristics of the study according to the level of treatment satisfaction.

* Mean difference is significant at P<0.05.

** Mean difference is significant at P<0.01.

Abbreviation: SD, standard deviation.

Table 2 Types of antidepressants and combination used in this study

Type of antidepressant drugs	Frequency	%
TCA	45	11.2
SSRI	211	52.4
SNRI	34	8.6
Other	47	11.8
TCA + SSRI	19	4.8
TCA + SNRI	5	1.6
SSRI + SNRI	21	5.3
SNRI + other	4	1.1
SSRI + SNRI + other	17	3.2
Total	403	100.0

Abbreviations: SNRI, serotonin-norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.

Table 3 Patient satisfaction with antidepressant and level of adherence

Factor	Low adherence (N =99)		High adherence (N =88)		t-value	P-value
	Mean	SD	Mean	SD
TSQM	80.83	14.27	85.72	9.62	2.775	0.006**
Effectiveness	78.38	16.95	83.39	14.26	2.169	0.031*
Side effects	71.32	15.44	70.91	14.97	0.070	0.944
Convenience	88.14	11.99	90.96	8.36	1.875	0.062
Global satisfaction	77.90	16.85	83.42	12.97	2.527	0.012**

Notes: Student’s t-test for the difference according to the level of adherence.

* Mean difference is significant at P<0.05.

** Mean difference is significant at P<0.01.

Abbreviations: TSQM, Treatment Satisfaction Questionnaire for Medication; SD, standard deviation.

Table 4 Pearson correlation coefficients between the factors of the TSQM and level of adherence and patient beliefs

Factor	General overuse	General harm	Necessity beliefs	Concern beliefs	Level of adherence
Effectiveness	−0.0338	0.0181	0.2913*	−0.2932**	0.0776
Side effects	0.1053**	0.1570**	−0.0264	−0.0303	−0.0948
Convenience	0.0130	−0.0478	0.2276*	−0.2061**	0.0403
Global satisfaction	−0.1247**	−0.1293**	0.4103*	−0.3338**	0.0938
TSQM	−0.0586	−0.1184**	0.3096*	−0.3046**	0.1104*

Notes:

* Direct positive correlation.

** Inverse negative correlation.

Abbreviation: TSQM, Treatment Satisfaction Questionnaire for Medication.