Magnetic seizure therapy in an adolescent with refractory bipolar depression: a case report

Figures & data

Figure 1 Longitudinal changes in clinical outcome measured with the HDRS₂₄. The red line indicates the remission score cut-off point of 10 on the HDRS₂₄.

Abbreviations: HDRS₂₄, 24-item Hamilton Depression Rating Scale; MST, magnetic seizure therapy.

Table 1 Neuropsychological battery at baseline, after acute treatment, and after continuation treatment

Attention				Executive functioning
Digit span (WAIS-III/WMS-III)			Total score	Trail making test			Time (seconds)
Baseline			17/30	Baseline			30
Post			18/30	Post			23
6 months post			21/30	6 months post			16
WAIS-III Digit symbol	Raw (90s)		Raw (120s)	Stroop		Number of responses
Baseline	57/133		87/133	Baseline	Word score	113
Post	49/133		74/133		Color task	91
6 months post	58/133		81/133		Color-word task	61
Memory functioning				Post	Word score	102
CVLT recall measures (number correct)	Baseline	Post	6 months post		Color task Color-word task	82 50
List A trials 1–5	68/80	66/80	69/80	6 months post	Word score	120
List A trial 1	13/16	9/16	9/16		Color task	93
List A trial 5	13/16	16/16	16/16		Color-word task	44
List B List A short-delay free recall	13/16 14/16	8/16 15/16	8/16 16/16	BVMT-R	Baseline raw score	Post raw score	6 months post
List A short-delay cued recall	14/16	15/16	16/16	Total recall	29/36	32/36	33/36
List A long-delay free recall	14/16	16/16	15/16	Delay recall	12/12	11/12	12/12
List A long-delay cued recall	14/16	16/16	15/16	Autobiographical memory
Perseverations (free/cued recall total)	20	5	9	AMI-SF			Total score
Free recall intrusions (total)	1	1	1	Baseline			52/60
Cued recall intrusions (total)	0	1	1	Post			35/60
Recognition hits	16/16	16/16	15/16	6 months post			35/60
List A trial 2	12/16	12/16	13/16
List A trial 3	15/16	14/16	15/16
List A trial 4	15/16	15/16	16/16

Abbreviations: AMI-SF, Autobiographical Memory Interview Short Form; BVMT-R, Brief Visuospatial Memory Test-Revised; CVLT, California Verbal Learning Test; WAIS-III, Wechsler Adult Intelligence Scale, Third Edition; WMS-III, Wechsler Memory Scale, Third Edition; s, seconds.

Table 2 Mean values during the acute and continuation treatment courses

	EEG seizure duration (seconds)	EMG seizure duration (sec)	Metho hexital sodium (mg)	Succinyl choline (mg)	Granisetron (mg)	Ondan setron (mg)	Pre-HR (bpm)	Post-HR (bpm)	Presystolic BP (mmHg)	Postsystolic BP (mmHg)	Prediastolic BP (mmHg)	Postdiastolic BP (mmHg)
Acute course MST	136±62	94±42	62±4	41±5	1±0	4±0	86±17	86±16	146±15	161±14	77±8	87±15
Continuation MST	170±33	146±28	61±3	30±0	0±0	4±0	112±18	85±13	151±4	165±12	80±5	84±8

Abbreviations: BP, blood pressure; EEG, electroencephalographic; EMG, electromyographic; HR, heart rate; MST, magnetic seizure therapy.