Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection

Figures & data

Table 1 The clinical characteristics of the patients and the results from CSF cultures and pathologic examinations of their intracranial lesions

		Number	%
Sex	Male	158	55.8
	Female	125	44.2
Age (years)	<20	66	23.3
	21–40	96	33.9
	41–60	93	32.9
	>60	28	9.9
Initial symptoms	Fever	271	95.8
	Headache	216	76.3
	Meningeal irritation	277	97.9
	Vomiting	93	32.9
	Lowering of consciousness	45	15.9
	Seizures	26	9.2
CSF culture results	Methicillin-resistant Staphylococcus aureus	10	28.6
	Acinetobacter baumannii	8	22.9
	Pseudomonas aeruginosa	6	17.1
	Escherichia coli	6	17.1
	Staphylococcus epidermidis	5	14.3
Benign lesions	Meningioma	36	72.1
	Cavernous hemangioma	9
	Spinal meningioma	19
	Craniopharyngioma	41
	Cerebrovascular malformation	18
	Hypophysoma	12
	Schwannoma	31
	Benign ependymoma	10
	Teratoma	5
	CNS epidermoid cyst	15
	CNS inflammatory demyelinating disease	2
	Arachnoid cyst	4
	CNS inflammatory granuloma	2
Malignant lesions	Astrocytoma	21	27.9
	Spongioblastoma	16
	Medulloblastoma	8
	Malignant ependymoma	5
	Oligodendroglioma	7
	Papilloma of choroid plexus	5
	Pineoblastoma	6
	Hemangioblastoma	7
	Malignant melanoma	2
	Metastatic carcinoma	2

Abbreviations: CSF, cerebrospinal fluid; CNS, central nervous system.

Table 2 Single-factor analysis of the variables affecting treatment duration: categorical data

	Total, n (%)	Treatment ≥15 days, n (%)	Treatment ≤14 days, n (%)	χ^2 value	P-value
Total	283 (100)	71 (25.1)	212 (74.9)
Sex
Male	158 (55.8)	47 (66.2)	111 (52.4)	0.815	0.042
Female	125 (44.2)	24 (33.8)	101 (47.6)
Hypertension
Yes	6 (2.1)	2 (2.8)	4 (1.9)	2.633	0.607
No	277 (97.9)	69 (97.2)	208 (98.1)
Diabetes
Yes	8 (2.8)	4 (5.6)	4 (1.9)	4.182	0.588
No	275 (97.2)	67 (94.4)	208 (98.1)
CSF culture
Positive	35 (12.4)	5 (7.0)	30 (14.2)	1.019	0.082
Negative	248 (87.6)	66 (93.0)	182 (85.8)
Postoperative drainage
Yes	63 (22.3)	15 (21.1)	48 (22.6)	1.443	0.791
No	220 (77.7)	56 (78.9)	164 (77.4)
Lumbar cistern drainage
Yes	72 (25.4)	20 (28.2)	52 (24.5)	1.287	0.544
No	211 (74.6)	51 (71.8)	160 (75.5)
Lesion nature
Benign	205 (72.4)	37 (52.1)	168 (79.2)	3.420	<0.001
Malignant	78 (27.6)	34 (47.9)	44 (20.8)

Abbreviation: CSF, cerebrospinal fluid.

Table 3 Single-factor analysis of the variables affecting treatment duration: continuous data

	Treatment ≥15 days	Treatment ≤14 days	t-value	P-value
Total, n (%)	71 (25.1)	212 (74.9)
Age (years)	43.1±6.2	42.0±5.9	0.984	0.790
CSF pressure (mmHg)	204.6±18.5	217.0±20.1	1.016	0.055
CSF white cell count (/mm^3)	511.4±42.6	498.5±54.2	0.843	0.372
CSF protein content (mg/dL)	207.1±25.3	223.6±27.2	0.902	0.213
CSF glucose content (mg/dL)	33.5±5.0	34.8±4.7	0.882	0.237

Note: Data are presented as the mean ± standard deviation, unless otherwise indicated. Abbreviation: CSF, cerebrospinal fluid.

Table 4 Logistic regression analysis of the variables affecting treatment duration

	Odds ratio	95% confidence interval
Sex	0.7140	0.2438–16.0844
Lesion nature	2.5962	1.1092–6.6134
CSF culture	0.8825	0.5238–27.3126
CSF pressure (mmHg)	0.6375	0.3116–36.4973

Abbreviation: CSF, cerebrospinal fluid.