Management of nightmares in patients with posttraumatic stress disorder: current perspectives

Figures & data

Table 1 Receptor-binding profiles of antipsychotics prescribed in the treatment of PTSD nightmares

	D1	D2	5HT1A	5HT2A	5HT2C	α1	α2	H1
Typical antipsychotics
Thioridazine	++	++	+	++	++	+++	0	++
Perphenazine	+	++++	+	+++	+	++	+	+++
Atypical antipsychotics
Olanzapine	++	++	0	+++	++	++	+	++++
Quetiapine	+	+	+	+	0	++	+	++
Ripseridone	++	+++	+	++++	++	+++	+++	+++
Aripiprazole	+	++++	+++	++	++	++	++	++

Notes: Affinity for receptors: 0=absent; +=low; ++=moderate; +++=high; ++++=very high. 5HT_1A, 5HT_2A, and 5HT_2C are known as serotonin receptors.

Abbreviations: α, alpha-adrenergic receptor; D, dopamine receptor; H, histamine receptor; 5HT, 5-hydroxytryptamine; PTSD, posttraumatic stress disorder.