Figures & data
Figure 1 The schematic timeline for study design. Two groups of animals received 5 weeks of physical exercise with a gradual increase in intensity (5 weeks, 5 days in a week); one of these groups (ExSd), 1 day after the last session of exercise received 24-hr REM-SD and other one went for MWM test. SD24 received 24-hr REM-SD after trial day of MWM and then probe test was performed. Control animals received nothing but MWM test. All animals were sacrificed after the visual test and their brain was collected for Western blotting test.
Figure 2 Effect of 24-hr REM-SD on memory impairment induced by intensive exercise. After 5 weeks of intensive exercise, ExSd group of animals received eight trials in a day and immediately went under 24-hr REM-SD. (A) Escape latency, (B) traveled distance and (C) swimming speed across eight trials. Values are given as mean±SEM for each experimental group. Probe test was done immediately after the 24-hr REM-SD. (D) Percentage of time spent in target quadrant. Data are shown as mean±SEM. *p˂ 0.05 and **p˂0.01 different from the control group. #p˂ 0.05 different from the Exercised group. ^^^p˂ 0.001 different from the 24h REM-SD group. Each bar represents mean±SEM per group. (E) Escape latency during non-spatial visible platform test. p>0.05 NS (not significant).
Figure 3 Effect of 24-hr REM-SD on the level of BDNF in the Ex group in the (A) hippocampus and (B) prefrontal cortex. Values are expressed as the means±SEM (n=5 for each group); effect of 24-hr REM-SD on the decreased level of TrkB in Ex group in (C) hippocampus and (D) prefrontal area in the rat. *P˂ 0.05, **P˂ 0.01 and ***P˂ 0.001 versus control, ^^p<0.01, ^^^P˂ 0.001 versus SD24 group and ###P˂ 0.001 versus Ex group.
